Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study

Table 5 Mean eGFRs and CKD prevalence for IL4T-33C and IL6C-572G genotypes combined

Genotype		n	eGFR (ml/min/1.73 m²)				CKD (eGFR < 60 ml/min/1.73 m²)
			mean ± SD	β^†	(95% CI)	P-value^†	n	(%)	OR^†	(95% CI)	P-value^†
IL4 TT/	IL6 CC	849	73.4 ± 14.4	0	(reference)	-	152	(17.9%)	1	(reference)	-
IL4 TC/	IL6 CC	854	74.5 ± 14.9	1.1	(-0.3-2.4)	0.108	140	(16.4%)	0.89	(0.75-1.06)	0.200
IL4 TT/	IL6 CG	512	72.5 ± 14.5	-0.8	(-2.8-1.1)	0.337	98	(19.1%)	1.08	(0.90-1.30)	0.387
IL4 TC/	IL6 CG	512	74.0 ± 15.2	0.2	(-3.1-3.5)	0.890	84	(16.4%)	0.94	(0.68-1.28)	0.686
IL4 CC /	IL6 CG	161	74.0 ± 14.4	0.3	(-3.8-4.4)	0.867	26	(16.1%)	0.89	(0.42-1.90)	0.768
IL4 TC/	IL6 GG	100	75.6 ± 17.0	2.1	(-1.5-5.7)	0.217	17	(17.0%)	0.94	(0.67-1.32)	0.720
IL4 CC /	IL6 CC	208	76.5 ± 14.6	3.1	(-1.2-7.4)	0.127	20	(9.6%)	0.48	(0.39-0.58)	< 0.001
IL4 TT/	IL6 GG	91	77.6 ± 15.4	4.2	(0.4-8.1)	0.036	9	(9.8%)	0.49	(0.37-0.63)	< 0.001
IL4 CC /	IL6 GG	34	79.1 ± 13.4	5.2	(0.3-10.2)	0.041	0	(0.0%)	0.00	-	-

^†adjusted for age, sex, hypertension, diabetes mellitus, and cardiovascular diseases. Standard errors were adjusted for study areas. eGFR = estimated glomerular filtration rate. CKD = chronic kidney disease. CKD is defined by eGFR < 60 ml/min/1.73 m².