Figure 1
From: A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy
Percutaneous kidney biopsy four weeks after the second kidney transplantation revealed de-novo MN and moderate tubulo-interstitial changes (a) and granular pseudolinear deposition of immunoglobulin G (IgG) along the epithelial surface of the glomerular basement membrane (GBM) (b). C3c-deposits along the GBM of the patient were present (c). In reverse, incubation of human kidney samples with serum from the patient showed immunofluorescent staining of the GBM, documenting the presence of anti-human-GBM alloantibodies in the patient (d).