Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis

Table 3 Comparison of clinical and laboratory parameters between children with mild and severe renal histological lesions

Values are median [range]; NS, not significant.
Mild mesangial cellularity is defined as 4–5 mesangial cells on per mesangial area (score < 2); severe is defined as > 5 mesangial cells on per mesangial area (score ≥ 2).
Mild glomerulosclerosis is defined as absent or less than 10 % of all biopsied glomeruli showing segmental adhesions or sclerosis (score < 2); severe is defined as ≥ 10 % glomeruli showing segmental adhesions or sclerosis (score ≥ 2).
Mild tubule‒interstitial damage is defined as tubular and interstitial lesions absent or very mildly focal (score < 2); severe is defined as focal or diffuse tubular and interstitial lesions (score ≥ 2).
*Clinical features: the patients were classified into five categories according to their renal manifestations at the time of biopsy: (1) micro‒ or macroscopic hematuria; (2) asymptomatic proteinuria with or without hematuria; (3) acute nephritic syndrome; (4) nephrotic syndrome; (5) Acute kidney injury. Classes 1 and 2 were considered as mild clinical features, and classes 3–5 as severe.

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