Comparing the association of GFR estimated by the CKD-EPI and MDRD study equations and mortality: the third national health and nutrition examination survey (NHANES III)

Table 4 Net reclassification improvement by the CKD-EPI equation among participants with eGFR <120 ml/min/1.73 m ² by both equations stratified by age, sex and race

	Reclassification, number (Population %)^a	Deaths,	NRI
		All-cause (CVD)	All-cause	CVD
Overall	11,808 (24.1%)	3,339 (1,463)	0.2073***	0.2216***
By Age Categories
17-44	4,822 (30.3%)	208 (58)	0.0216	−0.0883
45-64	3,491 (21.8%)	715 (258)	−0.0146	−0.0006
≥65	3,495 (11.4%)	2,416 (1,147)	0.1362***	0.0943***
By Sex
Male	5,839 (22.1%)	1,844 (796)	0.2077***	0.2277***
Females	5,969 (26.0%)	1,495 (667)	0.2063***	0.2157***
By Race/Ethnicity
NH Whites	5,736 (25.7%)	1,957 (903)	0.2258***	0.2368***
NH Blacks	2,701 (12.8%)	710 (290)	0.1245***	0.1229***
Mex-Am	2,868 (20.2%)	594 (239)	0.0648**	0.0682*
Others	503 (20.2%)	78 (31)	0.1427*	0.2559*** ^b

Abbreviations: eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease Study; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; NRI, Net Reclassification Improvement; NH, Non-Hispanic; Mex-Am, Mexican-American.
^a Reclassification to a different eGFR category by CKD-EPI equation. Number represents the number of participants; Population % is representative of the non-institutionalized US population.
^b NRI estimates less precise as there are <50 events in this cell.
* p < 0.05; ** p < 0.01; *** p < 0.001.

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