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Table 3 Glomerular and tubular function of 37 patients with ACL before and after specific treatment

From: Renal function evaluation in patients with American Cutaneous Leishmaniasis after specific treatment with pentavalent antimonial

 

Pre-glucantime (N = 37)

Post-glucantime (N = 37)

Control (N = 10)

P creat , (mg/dl)

0.81 ± 0.16

0.81 ± 0.15

0.85 ± 0.18

CrCl (ml/min/1.73 m 2 )

109.6 ± 31.5

108.4 ± 28.5

116.4 ± 22.7

U/P osm T4

2.19 ± 0.73

1.95 ± 0.73

3.47 ± 0.33

U pH T4

5.45 ± 0.64

5.19 ± 0.60*

4.82 ± 0.20 #

U osm T4

618 ± 202

552 ± 210

965 ± 81 #

FENa, (%)

1.15 ± 0.74

1.35 ± 1.51**

0.73 ± 0.39

FEk, (%)

10 ± 6.6

10.1 ± 7.6

7.50 ± 2.8#

FECa (%)

1.07 ± 0.72

1.32 ± 1.01

0.62 ± 0.34#

FEPO4 (%)

10.9 ± 9.98

10.9 ± 15.7

9.10 ± 6.4

FEMg (%)

1.81 ± 1.70

1.90 ± 1.44

0.90 ± 0.40#

Microalbuminuria (mg/g creatinine)

23.6 ± 26***

14.6 ± 18.9

6.12 ± 4.06

  1. * Pre vs. Post-glucantime, p = 0.0066; # control vs. Pre and post-glucantime, p < 0.05; **Post-glucantime vs. control, p = 0.048; ***pre vs. post-glucantime, p = 0.025. DATA: MEAN ± SD. Student t test, Mann–Whitney.
  2. Pcrea – SerumCreatinine.
  3. CrCl – Creatinine clearance.
  4. U/Posm – Urinary and serum osmolarity ratio.
  5. UpH em T4 – Urinary pH in T4.
  6. Uosm T4 – Urinary osmolality in T4.
  7. FE: fraction excretion.