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Table 2 The number of antihypertensive agents used in the patients with hypertension and diabetes at the baseline and at the endpoint of the observation

From: Hypertension resistant to antihypertensive agents commonly occurs with the progression of diabetic nephropathy in Japanese patients with type 2 diabetes mellitus: a prospective observational study

 

Albuminuria stage

 
 

A1

A2

A3

Average

GFR stage

Baseline$

Endpoint$

Baseline$

Endpoint$

Baseline$

Endpoint$

Baseline$

Endpoint$

G1 + G2

1.3 ± 1.0

1.7 ± 1.0

1.1 ± 1.0

1.7 ± 1.0

1.2 ± 0.8

2.0 ± 0.9

1.2 ± 1.0

1.7 ± 1.0

n (% of all)

261 (18.3)

182 (18.4)

127 (8.9)

79 (8.0)

58 (4.1)

37 (3.7)

446 (31.4)

298 (40)

G3a#

1.4 ± 1.0

1.7 ± 1.0

1.4 ± 1.1

1.8 ± 1.2

1.5 ± 0.9

2.3 ± 1.2

1.4 ± 1.0

1.8 ± 1.1

n (% of all)

269 (18.9)

217 (21.9)

140 (9.9)

82 (8.3)

86 (6.1)

68 (6.9)

495 (34.9)

367 (37.1)

G3b#

1.9 ± 1.1

2.1 ± 1.2

1.5 ± 1.3

2.0 ± 1.1

2.0 ± 1.3

2.6 ± 1.4

1.9 ± 1.3

2.3 ± 1.3*

n (% of all)

123 (8.7)

93 (9.4)

63 (4.4)

40 (4.0)

106 (7.5)

79 (8.0)

292 (20.6)

212 (21.4)

G4 + G5

3.0 ± 1.6

3.2 ± 1.8

2.4 ± 1.6

2.6 ± 1.2

2.5 ± 1.3

2.9 ± 1.4

2.5 ± 1.4

2.9 ± 1.4

n (% of all)

10 (1.0)

6 (0.9)

22 (1.5)

8 (0.8)

155 (10.9)

99 (10)

187 (13.2)

113 (11.4)

Average*#

1.5 ± 1.1

1.8 ± 1.1

1.4 ± 1.2

1.8 ± 1.1

2.0 ± 1.3

2.5 ± 1.4

1.6 ± 1.2

2.0 ± 1.3

n (% of all)

663 (46.7)

498 (50.3)

352 (24.8)

209 (21.1)

405 (28.5)

283 (28.6)

1420 (100)

990 (100)

  1. * P < 0.01 among A1, A2 and A3 at baseline and # P < 0.01 among A1, A2 and A3 at endpoint.
  2. $ P < 0.01 among G1 + G2, G2, G3 and G4 + G5.