Skip to main content

Table 2 Inflammatory and iron parameters in healthy volunteers and maintenance hemodialysis patients

From: Lower serum prohepcidin levels associated with lower iron and erythropoietin requirements in hemodialysis patients with chronic hepatitis C

 

Healthy volunteers (n = 20)

HD patients (n = 60)

P value

HCV (+) patients (n = 30)

HCV (−) patients (n = 30)

P value

Inflammatory parameters

      

hs-CRP (mg/L) median (25-75%)

1.83 (0.68-2.79)

8.35 (3.52-16.22)

0.005

12.20 (5.07-21.42)

5.45 (3.25-1.57)

0.181

TNF-alpha (pg/mL)

6.4 ± 4.6

68.0 ± 104.1

0.026

76.1 ± 61.0

61.0 ± 29.6

0.593

IL-6 (pg/mL)

3.5 ± 4.2

12.8 ± 10.1

0.021

9.1 ± 7.7

15.8 ± 10.9

0.016

Iron parameters

Iron (μg/dL) median (25-75%)

78 (60–118)

71 (57–98)

0.395

88 (66–130)

64 (44–75)

<0.001

TIBC (μg/dL)

289 ± 93

247 ± 50

0.156

229 ± 54

263 ± 41

0.012

TSAT (%)

37.2 ± 24.2

35.1 ± 21.4

0.771

46.9 ± 24.1

24.7 ± 11.6

<0.001

Ferritin (ng/mL)

77 ± 76

705 ± 420

<0.001

673 ± 503

699 ± 270

0.579

Prohepcidin (ng/mL)

137 ± 20

142 ± 23

0.417

135 ± 25

148 ± 18

0.025

Total iron need (mg/year) median (25-75%)

   

0 (0–200)

150 (0–425)

0.047

ESA resistance index

   

0.03 (0.00-6.51)

0.07 (0.00-6.58)

0.039

  1. Abbreviations: hs-CRP: high sensitive C-reactive protein, TNF-α: tumour necrosis factor alpha, IL-6: Interleukin-6, TIBC: total iron binding capacity, TSAT: Transferrin saturation, ESA: erythropoiesis-stimulating agent.