From: UT-B-deficient mice develop renal dysfunction and structural damage
16 weeks old | 52 weeks old | |||||
---|---|---|---|---|---|---|
Wild-type | UT-B-null | Relative difference (KO/WT) | Wild-type | UT-B-null | Relative difference (KO/WT) | |
Body weight, g | 24.12 ± 1.82 | 24.42 ± 1.10 | 1.01 | 37.08 ± 1.77 | 36.26 ± 2.31 | 0.98 |
Hydronephrotic kidneys/total kidneys | 0/45 | 0/42 | 0/33 | 12/39 | ||
Urine output, ml/day | 2.41 ± 0.08 | 4.05 ± 0.13* | 1.68 | 1.56 ± 0.11 | 2.5 ± 0.11# | 1.6 |
Urinary osmolality, mosm/kg H 2 O | 1622 ± 87 | 1012 ± 239* | 0.62 | 1463 ± 227 | 985 ± 151# | 0.67 |
Osmolar excretion, μmol/L | 3741 ± 314 | 4171 ± 792 | 1.11 | 2295 ± 400 | 2533 ± 281 | 1.1 |
Plasma creatinine, μmol/L | 29.6 ± 2.54 | 32 ± 2.02 | 1.08 | 28.53 ± 5.20 | 29.06 ± 1.29 | 1.02 |
Urinary creatinine, mmol/L | 2.49 ± 0.42 | 1.20 ± 0.10* | 0.48 | 3.28 ± 0.18 | 2.62 ± 0.25# | 0.8 |
U/P creatinine | 86.5 ± 17.6 | 37.9 ± 5.0* | 0.44 | 121.0 ± 16.2 | 90.1 ± 5.6 | 0.74 |
Creatinine clearance, ml/day | 198.1 ± 39.3 | 156.8 ± 22.1 | 0.79 | 188.1 ± 32.3 | 233.7 ± 23.9 | 1.24 |
Plasma urea, mmol/l | 10.94 ± 0.88 | 13.02 ± 0.63* | 1.19 | 15.36 ± 3.32 | 23.39 ± 6.22# | 1.52 |
Urinary urea, mmol/L | 904 ± 20 | 545 ± 15* | 0.6 | 755 ± 24 | 475 ± 10# | 0.63 |
Urea excretion, μmol/day | 2083 ± 125 | 2249 ± 127 | 1.08 | 1166 ± 55 | 1228 ± 63 | 1.05 |
Urea clearance, ml/day | 198.3 ± 26.3 | 169.5 ± 10.2* | 0.85 | 76.7 ± 8.3 | 50.4 ± 5.8# | 0.66 |
U/P Urea | 82.63 ± 7.61 | 41.86 ± 2.12* | 0.51 | 49.15 ± 1.85 | 20.31 ± 1.36# | 0.41 |