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Table 1 Water and solute handling.

From: UT-B-deficient mice develop renal dysfunction and structural damage

  

16 weeks old

  

52 weeks old

 
 

Wild-type

UT-B-null

Relative difference (KO/WT)

Wild-type

UT-B-null

Relative difference (KO/WT)

Body weight, g

24.12 ± 1.82

24.42 ± 1.10

1.01

37.08 ± 1.77

36.26 ± 2.31

0.98

Hydronephrotic kidneys/total kidneys

0/45

0/42

 

0/33

12/39

 

Urine output, ml/day

2.41 ± 0.08

4.05 ± 0.13*

1.68

1.56 ± 0.11

2.5 ± 0.11#

1.6

Urinary osmolality,

mosm/kg H 2 O

1622 ± 87

1012 ± 239*

0.62

1463 ± 227

985 ± 151#

0.67

Osmolar excretion, μmol/L

3741 ± 314

4171 ± 792

1.11

2295 ± 400

2533 ± 281

1.1

Plasma creatinine, μmol/L

29.6 ± 2.54

32 ± 2.02

1.08

28.53 ± 5.20

29.06 ± 1.29

1.02

Urinary creatinine, mmol/L

2.49 ± 0.42

1.20 ± 0.10*

0.48

3.28 ± 0.18

2.62 ± 0.25#

0.8

U/P creatinine

86.5 ± 17.6

37.9 ± 5.0*

0.44

121.0 ± 16.2

90.1 ± 5.6

0.74

Creatinine clearance, ml/day

198.1 ± 39.3

156.8 ± 22.1

0.79

188.1 ± 32.3

233.7 ± 23.9

1.24

Plasma urea, mmol/l

10.94 ± 0.88

13.02 ± 0.63*

1.19

15.36 ± 3.32

23.39 ± 6.22#

1.52

Urinary urea, mmol/L

904 ± 20

545 ± 15*

0.6

755 ± 24

475 ± 10#

0.63

Urea excretion, μmol/day

2083 ± 125

2249 ± 127

1.08

1166 ± 55

1228 ± 63

1.05

Urea clearance, ml/day

198.3 ± 26.3

169.5 ± 10.2*

0.85

76.7 ± 8.3

50.4 ± 5.8#

0.66

U/P Urea

82.63 ± 7.61

41.86 ± 2.12*

0.51

49.15 ± 1.85

20.31 ± 1.36#

0.41

  1. Values are means ± SE of 5 mice/group. U/P: urine/plasma. Comparisons were made using Student's t-test. *P < 0.05 versus 16-week-old wild-type mice, # P < 0.05 versus 52-week-old wild-type mice.