Skip to main content

Table 2 List of topics considered by stakeholders for Comparative Effectiveness Systematic Reviews

From: Setting an agenda for comparative effectiveness systematic reviews in CKD care

  Topic Example Question*
Prevention
1** Patient knowledge/education What is the effectiveness of strategies to improve patient knowledge or awareness of CKD and CKD risk factors on decreasing CKD incidence?
2 Hypertension What is the comparative effectiveness of hypertension management (pharmacologic and non-pharmacologic) on CKD incidence?
3 Diabetes control and prevention What is the comparative effectiveness of diabetes management (pharmacologic and non-pharmacologic) on CKD incidence?
4 Patient Safety What is the effectiveness of patient safety interventions on decreasing the incidence of acute kidney injury/CKD (i.e. exposure to contrast/dyes, nephrotoxins [NSAIDS])?
5 Smoking cessation and prevention What is the comparative effectiveness of smoking cessation strategies on CKD incidence?
6 Lipid management What is the comparative effectiveness of lipid management strategies on CKD incidence?
7 Vitamin D What is the effectiveness of normalizing Vitamin D levels among deficient or insufficient patients in preventing CKD?
8 Obesity/Weight Management What is the effectiveness of obesity/weight management interventions in decreasing CKD incidence?
Detection
9 Screening benefits and harms What are the benefits and harms of screening versus usual detection of CKD?
10 Screening frequency What is the optimal screening frequency in populations at high-risk of CKD incidence?
11 Classification Which estimations of GFR accurately classify people as having CKD? Including the correct stage?
12 Automated estimated GFR reporting Does automated estimated GFR reporting lead to changes in clinical management and outcomes (drugs/referral)?
Progression
13 Health Information Technology What is the effectiveness of computer decision support for CKD management (including medication dosing) in slowing CKD progression?
14 Hyperuricemia Is treatment of hyperuricemia an effective strategy for slowing CKD progression?
15 Inflammation What is the comparative effectiveness of strategies to reduce markers of inflammation (i.e. C-reactive protein) in slowing CKD progression?
16 Provider awareness and guideline adherence What is the effectiveness of strategies to improve provider awareness and adherence to guidelines on improving outcomes (progression) for patients with CKD?
17 Collaboration strategies What is the effectiveness of strategies to increase collaboration in care (i.e. primary care/nephrology and team based approaches) of CKD patients in slowing CKD progression?
18 Diabetes management What is the effectiveness and comparative effectiveness of diabetes management strategies (i.e. pharmacologic and behavioral strategies, therapeutic targets) in slowing CKD progression?
19 Vitamin D Is vitamin D therapy effective in slowing CKD progression?
20 Hypertension What is the comparative effectiveness of strategies to treat hypertension (i.e. target, medication combinations, behavioral strategies, lifestyle interventions) in slowing CKD progression?
21 Proteinuria Is targeted therapy to reduce proteinuria (ie. optimal proteinuria target, specific therapies) effective in slowing CKD progression?
22 Patient safety What is the effectiveness of patient safety interventions on slowing CKD progression?
23 Access to care Is improved access to care (including primary or nephrology care) an effective mechanism for slowing CKD progression?
24 Cardiovascular disease Are interventions to manage heart failure and coronary artery disease effective in slowing CKD progression?
25 Dietary strategies What is the effectiveness or comparative effectiveness of dietary strategies in slowing CKD progression?
26 Congenital urologic disease What is the effectiveness and comparative effectiveness of strategies to treat congenital urologic disease in slowing CKD progression?
27 Acute kidney injury What is the comparative effectiveness of management strategies of AKI in slowing CKD progression?
28 Preparation for renal replacement therapy What is the comparative of strategies (e.g., education, shared decision-making, fistula placement) to prepare patients for renal replacement therapy?
29 Metabolic acidosis Is treatment of metabolic acidosis an effective strategy for slowing CKD progression?
30 Anemia Is treatment of anemia an effective strategy for slowing CKD progression?
31 Dyslipidemia Is treatment of dyslipidemia an effective strategy in slowing CKD progression?
32 Renovascular disease Are renovascular interventions effective in slowing CKD progression?
Complications
33 Cardiovascular Disease (CVD) What is the effectiveness or comparative effectiveness of strategies to prevent or treat CVD among patients with CKD?
34 Patient Educational Interventions What is the effectiveness of patient educational interventions in reducing CKD complications?
35 Bone/Mineral Disease What is the effectiveness or comparative effectiveness of strategies to screen, evaluate and treat bone/mineral disease among patients with CKD?
36 Hypertension What is the effectiveness or comparative effectiveness of blood pressure management strategies among patients with CKD?
37 Inflammation What is the comparative effectiveness of strategies to reduce markers of inflammation (i.e., CRP) in slowing CKD progression?
38 Nutrition/Growth What is the effectiveness of strategies to prevent, evaluate, and treat poor growth and malnutrition among patients with CKD?
39 Health Information Technology What is the effectiveness of computer decision support for CKD management in reducing complications?
40 Collaborative Care What is the effectiveness of strategies to increase collaboration (i.e., primary care/nephrology and team based approaches) in care of CKD for reducing CKD complications?
41 Patient Safety What is the effectiveness of patient safety interventions in reducing complications among CKD patients?
42 Patient Reported Outcomes What is the effectiveness of interventions to improve patient reported CKD complications (i.e. symptoms, sexual dysfunction, quality of life)?
43 Anemia What is the effectiveness or comparative effectiveness of strategies to screen, evaluate, and treat anemia in patients with CKD?
44 Acute Kidney Injury What is the effectiveness or comparative effectiveness of strategies to prevent or treat acute kidney injury among patients with CKD?
45 Functional status What is the effectiveness of strategies to evaluate and improve functional status (i.e. rehabilitation interventions) among patients with CKD?
46 Fluid management What is the effectiveness or comparative effectiveness of treatment strategies for volume overload among patients with CKD?
  1. *Example questions are intended to illustrate ways in which CER topics can be framed, but are not intended to reflect questions themselves.
  2. **Topics are grouped by domain, in no particular order.