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Table 4 The selected combined effects of IL12 and IL18 polymorphisms in hemodialysis patients with a titre of antibodies to surface antigen of hepatitis B virus ≤ 10 UI/L (Group I) and > 10 UI/L (Group II)

From: Antibodies to hepatitis B virus surface antigen and interleukin 12 and interleukin 18 gene polymorphisms in hemodialysis patients

Variable

Group I (n = 207) n (%)

Group II (n = 311) n (%)

OR (95 % CI)

P value

Sample power (%) for significant differences

Combined effects of rs568408 and rs360719

rs568408 GG and rs360719 TT

90 (43.5)

115 (37.0)

1.00

  

rs568408 GG and rs360719 TC

62 (30.0)

88 (28.3)

0.90 (0.59 – 1.38)

0.629

 

rs568408 GG and rs360719 CC

5 (2.4)

17 (5.5)

0.38 (0.13 – 1.06)

0.048

45.7

rs568408 GG and rs360719 TC/CC

67 (32.4)

105 (33.8)

0.81 (0.54 – 1.23)

0.331

 

rs568408 GA and rs360719 TT

21 (10.1)

44 (14.1)

0.61 (0,34 – 1.10)

0.095

 

rs568408 GA and rs360719 TC

19 (9.2)

34 (10.9)

0.71 (0.38 – 1.34)

0.287

 

rs568408 GA and rs360719 CC

1 (0.48)

8 (2.6)

0.16 (0.02 – 1.32)

0.035

45.3

rs568408 GA and rs360719 TC/CC

20 (9.7)

42 (13.5)

0.61 (0.33 – 1.11)

0.099

 

rs568408 GA/AA and rs360719 TT

28 (13.5)

43 (13.8)

0.83 (0.48 – 1.45)

0.511

 

rs568408 GA/AA and rs360719 TC

21 (10.1)

38 (12.2)

0.71 (0.39 - 1,29)

0.252

 

rs568408 GA/AA and rs360719 CC

1 (0.48)

8 (2.6)

0.16 (0.02 – 1.32)

0.034

45.3

rs568408 GA/AA and rs360719 TC/CC

22 (10.6)

48 (15.4)

0.59 (0.33 – 1.04)

0.064

 

rs568408 AA and rs360719 TT

7 (3.4)

1 (0.32)

8.94 (1.07 – 74.94)

0.011

65.5

rs568408 AA and rs360719 TC

2 (0.97)

4 (1.3)

0.64 (0.11 – 3.60)

0.602

 

rs568408 AA and rs360719 CC

0 (0)

0 (0)

-

-

 

Combined effects of rs3212227 and rs360719

rs3212227 AA and rs360719 TT

76 (36.7)

102 (32.8)

1.00

  

rs3212227 AA and rs360719 TC

48 (23.2)

73 (23.5)

0.88 (0.55 – 1.41)

0.602

 

rs3212227 AA and rs360719 CC

5 (2.4)

18 (5.8)

0.37 (0.13 – 1.05)

0.046

49.4

rs3212227 AA and rs360719 TC/CC

53 (25.6)

91 (29.3)

0.78 (0.50 – 1.23)

0.283

 

rs3212227 AC and rs360719 TT

40 (19.3)

52 (16.7)

1.03 (0.62 – 1.72)

0.902

 

rs3212227 AC and rs360719 TC

29 (14.0)

51 (16.4)

0.76 (0.44 – 1.32)

0.328

 

rs3212227 AC and rs360719 CC

1 (0.48)

7 (2.3)

0.19 (0.02 – 1.61)

0.068

 

rs3212227 AC and rs360719 TC/CC

30 (14.5)

59 (19.0)

0.68 (0.40 – 1.16)

0.155

 

rs3212227 AC/CC and rs360719 TT

42 (20.3)

58 (18.6)

0.97 (0.59 – 1.60)

0.910

 

rs3212227 AC/CC and rs360719 TC

35 (16.9)

53 (17.0)

0.89 (0.52 – 1.49)

0.649

 

rs3212227 AC/CC and rs360719 CC

1 (0.48)

7 (2.3)

0.19 (0.02 – 1.61)

0.068

 

rs3212227 AC/CC and rs360719 TC/CC

36 (17.4)

60 (19.3)

0.80 (0.48 – 1.34)

0.403

 

rs3212227 CC and rs360719 TT

2 (0.97)

6 (1.9)

0.45 (0.09 – 2.30)

0.307

 

rs3212227 CC and rs360719 TC

6 (2.9)

2 (0.64)

4.03 (0.78 – 20.72)

0.069

 

rs3212227 CC and rs360719 CC

0 (0)

0 (0)

-

-

 

rs3212227 CC and rs360719 TC/CC

6 (2.9)

2 (0.64)

4.03 (0.78 – 20.72)

0.069

 
  1. Significant results are indicated using bold font.