Table 3 Characteristics of ADPKD patients screened for PKD2 mutations. ns = not significant

Number (%)

115 (80.3)

27 (19.7)

Male:female

0.59

0.59

Age at clinic presentation y

49.0 ± 13.3

49.5 ± 14.8

ns

Age at diagnosis y

37.4 ± 15.4

42.6 ± 14.4

ns

Hypertensive at diagnosis %

42.6

40.7

ns

Treatment for hypertension %

84.3

70.4

ns

Progression to ESRF %

12.2

0

p < 0.03

eGFR at presentation ml/min/1.73 m²

67.0 ± 27.6

74.0 ± 28.4

ns

No FH of ADPKD %

35.6

25.9

ns

FH with ESRF %

50.4

40.7

ns

FH with no ESRF %

13.9

33.4

p < 0.03

Median age of family member at ESRF y (range)

54.1 (33–83)

65.5 (50–86)

p < 0.0001

Number with FH ESRF < 50 yrs

31

0

Number with FH ESRF < 60 yrs

69

4

Number with FH ESRF < 70 yrs

81

9

Number with FH ESRF ≥ 70 yrs

8

6

Number of family members with ESRF (where age known)

89

15