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Table 1 Characteristics of the studied population

From: Determination of the best method to estimate glomerular filtration rate from serum creatinine in adult patients with sickle cell disease: a prospective observational cohort study

 

Whole population (n = 64)

Patients with SS genotype (n = 41)

Patients with non- SS genotype (n = 23)

p value * SS vs non-SS

 

(n = 64)

(n = 41)

(n = 23)

 

Sex ratio (M/F), (M%)

16/48 (25.0%)

11/30 (27%)

5/18 (22%)

0.22

Age, years

27.5 [18–67.5]

26.8 [18–49.5]

31.7 [18–67.5]

0.03

Ethnical origin

   

0.74

Sub Saharian Africa

48 (75%)

32 (78.1%)

16 (69.6%)

 

French West Indies

10 (15.6%)

6 (14.6%)

4 (17.4%)

 

Maghreb

2 (3.1%)

1 (2.4%)

1 (4.3%)

 

Other

4 (6.3%)

2 (4.9%)

2 (8.7%)

 

Height, m

1.67 [1.48-1.83]

1.68 [1.53-1.83]

1.66 [1.48-1.78]

0.27

Weight, kg

63 [43.5-90]

61.5 [43.5-81]

64 [45–90]

0.03

Body mass index, kg/m2

22 [16–33]

21 [16–30]

24 [16–33)]

0.017

Hemoglobin, g/dL

8.9 [5.5-14.3]

8.2 [5.5-12.6]

10.7 [7.5-14.3]

<0.001

Reticulocyte count, ×103/mm3

170 [32–466]

219 [32–466]

99 [34–271]

<0.001

Plasma creatinine, μmol/L

55 [27–113]

48 [27–76]

65 [51–113]

<0.001

mGFR, mL/min/1,73 m2

112.5 [29–183]

119 [65–183]

98 [29–163]

<0.002

GFR >110 mL/min/1,73 m 2

34 (53.1%)

28 (68.3%)

6 (26.1%)

0,0017

Urinary albumin/creatinine, mg/mmol

2.87 [0.07-134]

4.84 [0.14-80.6]

0.63 [0.07-134]

0.005

No albuminuria (<3 mg/mmol)

32 (50%)

16 (39%)

16 (69.5%)

 

Microalbuminuria

23 (36%)

17 (41.5%)

6 (26.1%)

 

Macroalbuminuria (>30 mg/mmol)

9 (14%)

8 (19.5%)

1 (4.3%)

0 .053

  1. Results are expressed as numbers (%) or median [range].
  2. M: male, F: female,
  3. mGFR: glomerular filtration rate measured by iohexol plasma clearance.
  4. * Tests are either Chi-square or Fisher’s exact test for categorical variables or Kruskall-Wallis test (more than two groups) or the Mann–Whitney test (two groups) for continuous variables.