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Figure 3 | BMC Nephrology

Figure 3

From: Chronic kidney disease, severe arterial and arteriolar sclerosis and kidney neoplasia: on the spectrum of kidney involvement in MELAS syndrome

Figure 3

Overview of cortical atrophy: the thickness of the renal parenchyma is severely reduced (only 3 mm between the renal capsule (1) and the arcuate artery (2)). There is widespread interstitial fibrosis, with dense inflammatory infiltrate (3), some tubules are atrophic with either the classical pattern (4) or with thyroidization type (5), some residual tubules are hypertrophic (6). The arcuate artery shows a severe narrowing of the lumen by marked intimal fibrosis (PAS stain). In the box: The figure shows the different patterns of glomeruli: normal (a), ischemic or obsolescent (b), focal segmental glomerulosclerosis (c) (Masson trichromatic stain)

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