Figure 2

Wild type recipients of mutant bone marrow do not exhibit PKD. (A and B) Compared to an age matched wild type control (A), 12 wk old homozygous orpk mice (B) exhibited features of PKD including cysts (#), dilated tubules (arrow) and increase in the cellularity of the interstitium (*). (C) Wild type female mice transplanted with mutant bone marrow demonstrated complete renal repair 12 wks after injury and did not exhibit the histopathology associated with PKD. Scale bar in C = 100 μm and A & B are at the same magnification as C.