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Table 1 Clinical characteristics of patients

From: Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction: a post-hoc analysis of a multicenter randomized controlled trial

Baseline characteristics All MBL ≤500 ng/mL MBL >500 ng/mL P-value
  (n = 246) (n = 57) (n = 189)  
Age in years, mean (SD) 75 (9.4) 74 (10.5) 75 (9.5) 0.4
Female sex, n (%) 89 (36) 24 (42) 65 (34) 0.4
MBL in ng/mL, median (IQR) 2150 (560–3794) 127 (11–330) 2855 (1701–4347) n/a
BMI in kg/m2, median (IQR) 26 (23–29) 27 (24–30) 26 (23–29) 0.09
Contrast medium in mL, median (IQR) 100 (80–160) 100 (80–150) 100 (80–170) 0.3
Medical history     
Hypertension, n (%) 204 (83) 48 (84) 156 (83) 0.8
D.m., n (%) 90 (37) 19 (33) 71 (38) 0.6
Dyslipidemia, n (%) 145 (59) 34 (60) 111 (59) 1.00
Coronary heart disease, n (%) 143 (58) 31 (54) 112 (59) 0.5
CHF, n (%) 111 (45) 23 (40) 88 (47) 0.5
Peripheral artery disease, n (%) 64 (26) 11(19) 53 (28) 0.2
Current smoking, n (%) 40 (16) 7 (12) 33 (17) 0.4
Medication     
ACE-Inhibitor, n (%) 108 (44) 23 (40) 85 (45) 0.7
AT-II-Inhibitor, n (%) 69 (28) 13 (23) 56 (30) 0.40
Diuretics, n (%) 173 (70) 41 (72) 132 (70) 0.9
NSAIDs, n (%) 8 (3) 5 (9) 3 (2) 0.02
Baseline parameters     
Systolic BP in mmHg, median (IQR) 130 (120–146) 132 (120–149) 130 (117–145) 0.1
Diastolic BP in mmHg, median (IQR) 70 (60–80) 76 (65–80) 70 (60–80) 0.01
Creatinine in μmol/L, median (IQR) 137 (114–162) 140 (113–154) 136 (114–164) 0.9
Cystatin C in mg/L, median (IQR) 1.7 (1.5-2.0) 1.8 (1.5-2.0) 1.7 (1.5-2.1) 0.8
eGFR in mL/min/1.73 m2, median (IQR) 44 (35–52) 44 (35–51) 44 (35–53) 0.8
Type of procedure     
Coronary angiogram, n (%) 110 (45) 23 (40) 87 (46) 0.5
PCI, n (%) 52 (21) 12 (21) 40 (21) 1.00
CT scan, n (%) 110 (45) 29 (51) 81 (43) 0.3
Other, n (%) 26 (11) 5 (9) 21 (11) 0.8
Intervention group     
Standard 24 h sodium chloride, n (%) 85 (35) 16 (28) 69 (37) 0.3
7 h sodium bicarbonate, n (%) 82 (33) 22 (39) 60 (32) 0.3
Short-term sodium bicarbonate, n (%) 79 (32) 19 (33) 60 (32) 0.9
  1. P-values are given for the difference between MBL ≤500 and >500 ng/ml. Abbreviations: D.m. = Diabetes mellitus; IQR = interquartile range; BMI = body mass index; CHF = congestive heart failure class I/II by New York Heart Association classification; NSAIDs = non-steroidal anti-inflammatory drugs; eGFR = estimated glomerular filtration rate; CT scan = computer tomography scan. PCI = percutaneous coronary intervention; BP = blood pressure; SD = standard deviation.