Table 2 Calcification scores and biochemical characteristics of study groups (mean & 95% CI)
Hemodialysis group | Control group | Statistical significance | |
|---|---|---|---|
(N = 104) | (N = 14) | ||
CACS | 941 (645–1238) | 182 (0–405) | <0.001 |
AACS | 2773 (2078–3470) | 431 (0–945) | <0.001 |
Hematocrit (%) | 33.6 (32.8-34.5) | 40.9 (38.5-43.3) | <0.001 |
Hemoglobin (g/dL) | 11.1 (10.8-11.4) | 14.0 (13.2-14.8) | <0.001 |
Albumin (g/dL) | 3.87 (3.76-3.97) | 4.06 (3.82-4.31) | 0.26 |
Creatinine (μmol/L) | NA | 77 (66–88) | |
Total cholesterol (mmol/L) | 4.63 (4.37-4.88) | 5.43 (4.88-5.97) | 0.02 |
LDL cholesterol (mmol/L) | 2.61 (2.39-2.83) | 3.17 (2.71-3.64) | 0.04 |
HDL cholesterol (mmol/L) | 1.14 (1.06-1.23) | 1.54 (1.26-1.83) | 0.002 |
Triglycerides (mmol/L) | 1.94 (1.67-2.22) | 1.44 (0.72-2.15) | 0.02 |
Dyslipidemia (n /%) | 75 / 72.1 | 11 / 78.6 | 0.85 |
Calcium (mmol/L) | 2.17 (2.14-2.20) | 2.26 (2.22-2.31) | 0.02 |
Phosphorous (mmol/L) | 1.88 (1.74-2.03) | 1.04 (0.95-1.13) | <0.001 |
Parathyroid hormone (pg/mL) | 409 (313–506) | 50 (40–61) | <0.001 |
25(OH)D3 (ng/mL) | 22.9 (17.7-28.1) | 28.0 (16.5-39.4) | 0.34 |
iFGF-23 (ng/mL) | 662.9 (464.3-861.4) | 6.3 (5.6-6.9) | <0.001 |
Osteocalcin (pmol/L) | 39.2 (31.1-47.3) | 5.4 (3.9-6.8) | <0.001 |
Osteopontin (ng/mL) | 103.2 (93.5-112.8) | 27.8 (23.8-31.8) | <0.001 |
Osteoprotegerin (pmol/L) | 14.7 (12.0-17.3) | 5.0 (3.8-6.1) | <0.001 |
Matrix GLA protein (nmol/L) | 11.1 (10.2-11.9) | 13.6 (12.2-14.9) | 0.01 |
Fetuin-A (g/L) | 0.63 (0.55-0.70) | 0.70 (0.56-0.84) | 0.13 |
CRP (mg/L) | 12.6 (9.2-16.1) | 1.2 (0.8-1.6) | <0.001 |
IL-6 (pg/mL) | 7.3 (5.4-9.1) | 2.6 (1.3-3.8) | <0.001 |
TNF-α (pg/mL) | 10.6 (8.8-12.4) | 1.8 (1.0-2.5) | <0.001 |