Tubulointerstitial fibrosis in CsA-treated rat kidneys. A: Vehicle (VH), B: Bilirubin (BIL) C: CsA, and D: BIL + CsA groups (MT staining, magnification × 200). Semiquantitative scoring of E: tubulointerstitial fibrosis and F: tubular injury according to mean percentage of injured area obtained in at least 20 fields from the A, B, C and D groups. Compared with CsA group, BIL + CsA group showed improved tubulointerstitial fibrosis. The data are the means ± SD. *P < 0.05 vs. VH, †P < 0.05 vs. BIL, and ‡P < 0.05 vs. CsA.