Figure 2

Body weight and biochemical parameters during the study. A: Body weight and renal function parameters during the study. ΔBody weight (top): Body weight was reduced during the 10-day induction phase in the adenine-treated group but remained stable during the maintenance phase until endpoint. Markers of kidney function: serum urea, serum creatinine/body weight, urine urea/serum urea and urine creatinine/serum creatinine indicated reduced renal clearance rate in adenine-treated mice. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. B: Temporal changes in serum biochemistries of mineral metabolism. At endpoint, there was a significant increase in serum inorganic phosphorous, PTH and FGF23 but a decrease in 1,25(OH)₂D level in adenine-treated mice. The bone marker CTX was decreased and PINP borderline increased in the adenine group, supporting a reduced bone resorption but increased bone formation. *p < 0.05; **p < 0.01.