Expression of renal-derived inflammatory and fibrosis genes. A) Inflammatory markers Mmp3, Mmp9, Il7rα, Ccl20 and Ccl5, and B) Marker of fibrosis Tgfb1, Col1a1 and Ccl2 were upregulated in adenine treated mice. Relative gene expression in the control group is set to 1. White bars; control group, black bars; adenine group. ***p < 0.001.