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Table 1 Histopathological evaluation of kidneys from control and adenine-treated mice

From: A novel model of adenine-induced tubulointerstitial nephropathy in mice

Compartment Parameter Control group Adenine group
(n = 5) (n = 8)
Glomeruli Sclerosis (present/absent) 0/5 0/8
Dilatation of Bowmans capsules (present/absent) 0/5 5/3
Tubuli Rounded cristalloid/amorphous structures in tubular lumina (present/absent) 0/5 8/0
Cell debris/necrotic material and PMN in tubular lumina (0–3) 0 (0–0) 1 (1–1)
Tubular atrophy (0–3) 0 (0–0) 2 (2–3)
Thyroidization (0–3) 0 (0–0) 1 (1–2)
Focal dilatation of tubuli (present/absent) 0/5 6/2
Focal calcium deposits (present/absent) 0/5 5/3
Interstitium Fibrosis (0–3) 0 (0–0) 1 (1–1)
Inflammation (0–3) 0 (0–0) 0 (0–1)
Vessels Morphology (pathological/normal) 0/5 0/8
  1. The parameters tubular atrophy, cell debris/necrotic material and polymorphonuclear leukocytes (PMN) in tubular lumina, thyroidization, interstitial fibrosis and interstitial inflammation are graded as follows: 0; affecting 0-5% of the renal area, 1; 6-25%, 2; 26-50%, and 3; >50%. Data is presented as median (range). Rounded cristalloid/amorphous structures in tubular lumina, focal dilatation and focal calcium deposits in tubuli are graded as present or absent. Vessel morphology is graded as pathological or normal.