B-type natriuretic peptide versus amino terminal pro-B type natriuretic peptide: selecting the optimal heart failure marker in patients with impaired kidney function

Table 4 Potential BNP and NT-proBNP cut off levels for the assessment of systolic heart failure according CKD staging

Natriuretic peptide	Group	Optimal cut point (pg/ml)	Sensitivity	Specificity
			%	%
BNP	Stage 3 CKD	146	60	65.9
BNP	Stage 4 CKD	309.4	60	78.4
BNP	Stage 5 CKD	491	60	88.2
NT-proBNP	Stage 3 CKD	1505.8	72.2	92.7
NT-proBNP	Stage 4 CKD	7767.5	70	91.9
NT-proBNP	Stage 5 CKD	11215.2	94.7	100

Abbreviations: BNP B-type natriuretic peptide, NT-proBNP amino terminal B-type natriuretic peptide, AUC area under the curve, CKD chronic kidney disease.

ISSN: 1471-2369