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Table 1 Baseline characteristics stratified by eGFR level

From: Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT)

Variables All eGFR Level Pvalue
< 20 ml/min 20-29 ml/min ≥ 30 ml/min
N 2402 533 (22%) 933 (39%) 936 (40%)  
Age (in years) 68.1 (12.7) 66.9 (13.5) 68.7 (12.6) 68.3 (12.3) 0.033
Gender (% Male) 1502 (63%) 311 (58%) 569 (61%) 622 (66%) 0.004
Race (% Caucasian) 2142 (89%) 471 (88%) 834 (89%) 837 (89%) 0.79
Diabetes 1160 (48%) 251 (47%) 480 (51%) 429 (46%) 0.043
Primary Kidney Disease      
 Diabetic Nephropathy 699 (29%) 167 (31%) 291 (31%) 241 (26%) <0.0001
 Hypertensive Nephropathy 637 (27%) 124 (23%) 248 (27%) 265 (28%)
 Glomerulonephritis 273 (11%) 75 (14%) 104 (11%) 94 (10%)
 Polycystic Kidney Disease 103 (4%) 29 (5%) 33 (4%) 41 (4%)
 Other 690 (29%) 138 (26%) 254 (28%) 295 (32%)
eGFR mL/min/1.73m 2 27.9 (9.0) 16.8 (2.0) 24.9 (2.9) 37.2 (5.6) <0.0001
Albumin g/L 40.4 (4.2) 39.7 (4.5) 40.4 (4.1) 40.8 (4.3) <0.0001
Hemoglobin g/L 122 (16) 117 (14) 123 (14) 127 (17) <0.0001
Cholesterol mmol/L 4.25 (1.17) 4.13 (1.21) 4.28 (1.09) 4.29 (1.23) 0.17
Calcium mmol/L 2.30 (0.14) 2.27 (0.15) 2.30 (0.14) 2.32 (0.14) <0.0001
Phosphate mmol/L 1.22 (0.26) 1.37 (0.26) 1.22 (0.22) 1.13 (0.24) <0.0001
1,84 Parathyroid Hormone pg/mL 44 (21–69) 76 (46–122) 41 (31–85) 33 (20–48) <0.0001
Bicarbonate mmol/L 25.4 (3.6) 24.1 (4.0) 25.1 (3.4) 26.6 (3.2) <0.0001
ACR mg/mmol 16 (3–88) 54 (13–209) 18 (3–87) 7 (2–43) <0.0001
ACR      
 < 3.4 mg/mmol 632 (27%) 50 (11%) 222 (25%) 348 (36%) <0.0001
 3.4-33.9 mg/mmol 818 (34%) 137 (30%) 321 (36%) 347 (36%)
 34.0-113.0 mg/mmol 410 (17%) 109 (24%) 157 (17%) 137 (14%)
 > 113.0 mg/mmol 512 (22%) 167 (36%) 198 (22%) 137 (14%)
Cystatin C ng/mL 1888 (539) 2419 (469) 1957 (424) 1519 (373) <0.0001
ADMA μM 0.543 (0.113) 0.557 (0.117) 0.548 (0.113) 0.529 (0.112) <0.0001
NT-pro-BNP pg/mL 465 (186–1359) 771 (297–2350) 515 (227–1235) 314 (130–940) <0.0001
CRP mg/L 2.9 (1.2-6.7) 3.4 (1.4-7.3) 2.9 (1.1-6.7) 2.7 (1.1-6.1) 0.026
TGF β1 pg/mL 19838 (15919–25085) 18343 (14365–22865) 19803 (15936–24729) 21043 (16678–26467) <0.0001
IL6 μg/L 4.4 (1.0-7.1) 4.8 (1.0-7.8) 4.5 (1.0-7.2) 4.1 (1.0-6.7) <0.0001
Troponin I > LLD 910 (37%) 244 (44%) 360 (38%) 306 (31%) <0.0001
25-hydroxyvitamin D ng/mL 23.9 (16.3-33.4) 21.2 (14.4-30.9) 23.7 (16.0-33.5) 26.0 (17.9-35.0) <0.0001
  1. *LLD: Lower Detection Limit.