Table 3 Clinical course and outcomes of critically ill pH1N1 patients, stratified by AKI
Overall | AKI | No AKI | P value | |
|---|---|---|---|---|
(n = 562) | (n = 342) | (n = 220) | ||
Day 1 support, physiology, and laboratory values | ||||
APACHE II score (n = 508, 306, 202) | 21.1 (9.2) | 23.0 (9.6) | 18.1 (7.6) | <0.0001 |
SOFA score (n = 361, 216, 145) | 11.2 (3.8) | 12.0 (3.8) | 9.7 (3.2) | <0.0001 |
Invasive mechanical ventilation (n = 553, 338, 215) | 384 (69.4) | 241 (71.3) | 143 (66.5) | 0.23 |
Inotrope or vasopressor | 251 (44.7) | 164 (48.0) | 87 (39.6) | 0.05 |
Mean arterial pressure (mmHg) (n = 522, 315, 207) | 74 (19) | 73 (19) | 76 (19) | 0.14 |
Heart rate (beats/min) (n = 433, 262, 171) | 104 (24) | 106 (25) | 102 (22) | 0.07 |
Temperature (°C) (n = 405, 244, 161) | 37.6 (1.2) | 37.6 (1.3) | 37.7 (1.2) | 0.84 |
PaO2/FiO2 (n = 496, 299, 197) | 153 (96) | 143 (94) | 167 (98) | 0.006 |
CK (U/L) (n = 230, 137, 93) | 293 (91-835) | 320 (102-949) | 206 (90-681) | 0.08 |
CK > 5000 IU/L (n = 230, 137, 93) | 13 (5.7) | 10 (7.3) | 3 (3.2) | 0.19 |
WBC (109/L) (n = 409, 243, 166) | 9.6 (6.5) | 9.7 (6.8) | 9.3 (6.0) | 0.45 |
Albumin (g/L) (n = 275, 167, 108) | 26.2 (7.0) | 26.1 (7.1) | 26.4 (7.0) | 0.77 |
Platelets (109/L) (n = 520, 313, 207) | 188 (96) | 184 (95) | 194 (96) | 0.26 |
Urea (mmol/L) (n = 76, 44, 32) | 10.5 (21.0) | 14.4 (26.9) | 5.1 (2.8) | 0.03 |
Creatinine (μmol/L) (n = 537, 326, 211) | 124 (120) | 155 (144) | 76 (31) | <0.0001 |
Urine output (mL/24 hr) (n = 431, 270, 161) | 1439 (1055) | 1070 (939) | 2058 (946) | <0.0001 |
Clinical course and outcomes | ||||
Invasive mechanical ventilation | 499 (88.8) | 313 (91.5) | 186 (84.6) | 0.01 |
Inotropes or vasopressors | 339 (60.3) | 222 (64.9) | 117 (53.2) | 0.006 |
Antiviral treatment | 530 (94.3) | 326 (95.3) | 204 (92.7) | 0.20 |
Renal replacement therapy (n = 561, 342, 219) | 85 (15.2) | 85 (24.9) | 0 | <0.0001 |
Days of hospital stay (n = 523, 319, 204) | 19.0 (12.0-35.0) | 20.0 (12.0-40.0) | 17.0 (12.0-30.0) | 0.13 |
Days of ICU stay (n = 539, 325, 214) | 11.0 (7.0-20.0) | 12.0 (7.0-24.0) | 10.0 (6.0-16.0) | 0.002 |
Hospital mortality (n = 545, 329, 216) | 113 (20.7) | 85 (25.8) | 28 (13.0) | 0.0003 |