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Table 5 Logistic regression model for acute kidney injury in critically ill pH1N1 patients

From: Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study

Variable

AKI

No AKI

Crude OR

P value

Adjusted OR

P value

n = 342

n = 220

(95% CI)

(95% CI)

H1N1 details, demographics, and comorbidities

Confirmed H1N1

291 (85.1)

188 (85.5)

0.97 (0.60-1.57)

0.90

  

Age (yr)

49.1 (15.1)

46.4 (14.8)

1.01 (1.00-1.02)

0.03

1.00 (0.98-1.02)

0.98

Female sex

177 (51.8)

123 (55.9)

0.85 (0.60-1.19)

0.34

0.86 (0.56-1.32)

0.50

Ethnicity (n = 555, 336, 219)

  White/Caucasian (reference)

204 (60.7)

123 (56.2)

1.00

 

1.00

 

  Unknown/Mixed/ Other

68 (20.2)

49 (22.4)

0.84 (0.54-1.29)

0.42

0.80 (0.46- 1.39)

0.43

  Aboriginal

47 (14.0)

27 (12.3)

1.05 (0.62-1.77)

0.86

1.01 (0.52-1.94)

0.98

  Asian

17 (5.1)

20 (9.1)

0.51 (0.26-1.02)

0.06

0.82 (0.35-1.89)

0.64

Obesity

118 (34.5)

32 (14.6)

3.10 (2.00-4.79)

<0.0001

2.94 (1.75-4.91)

<0.0001

Diabetes mellitus

107 (31.3)

39 (17.7)

2.11 (1.40-3.20)

0.0004

1.61 (0.96-2.69)

0.07

Chronic obstructive pulmonary disease

56 (16.4)

42 (19.1)

0.83 (0.53-1.29)

0.41

  

Alcohol abuse

41 (12.0)

33 (15.0)

0.77 (0.47-1.26)

0.30

  

Chronic kidney disease

44 (12.9)

4 (1.8)

7.97 (2.82-22.5)

<0.0001

4.50 (1.46-13.82)

0.009

Day 1 support, physiology, and laboratory values

APACHE II score (n = 508, 306, 202)

23.0 (9.6)

18.1 (7.6)

1.07 (1.04-1.09)

<0.0001

1.06 (1.03- 1.09)

<0.0001

Invasive mechanical ventilation (n = 553, 338, 215)

241 (71.3)

143 (66.5)

1.25 (0.86-1.81)

0.23

  

Inotrope or vasopressor

164 (48.0)

87 (39.6)

1.41 (1.00-1.99)

0.05

1.29 (0.82-2.01)

0.27

Mean arterial pressure (mmHg) (n = 522, 315, 207)

73.4 (18.7)

75.9 (19.2)

0.93 (0.85-1.02)

0.14

0.95 (0.85-1.06)

0.32

PaO2/FiO2 (n = 496, 299, 197)

143 (94)

167 (98)

0.97 (0.96-0.99)

0.007

0.98 (0.95- 1.00)

0.04

Platelets (109/L) (n = 520, 313, 207)

184 (95)

194 (96)

0.99 (0.97-1.01)

0.26

  
  1. Categorical data are presented as n (%) and continuous data as mean (SD). Heart rate, temperature, creatine kinase, WBC, albumin, and urea were excluded due to a high proportion of missing data. SOFA score was excluded because it was highly collinear with APACHE II score (Pearson r = 0.6). Urine output and creatinine were excluded because they were used to define the outcome. For each variable, we specify n when it differs from the totals in the first row. The final model included 442 patients and did not have evidence of lack of goodness of fit (p = 0.40). ORs for continuous variables refer to an increment of 1 unit (age, APACHE II) or 10 units (mean arterial pressure, PaO2/FiO2, platelets).
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