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Table 7 Logistic regression model for hospital mortality in critically ill H1N1 patients

From: Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study

Variable

Deaths

Survivors

Crude OR

P value

Adjusted OR

P value

(n = 113)

(n = 432)

(95% CI)

(95% CI)

H1N1 details, demographics, and comorbidities

Confirmed H1N1

104 (92.0)

364 (84.3)

2.16 (1.04-4.47)

0.04

1.59 (0.66-3.80)

0.30

Days of symptoms before hospitalization

5.5 (5.5)

5.2 (4.6)

1.01 (0.97-1.06)

0.55

  

Days of symptoms before ICU admission (n = 534, 110, 424)

7.2 (6.5)

6.2 (5.1)

1.03 (1.00-1.07)

0.08

1.04 (1.00-1.09)

0.06

Age (yr)

51.8 (15.6)

47.0 (14.6)

1.02 (1.01-1.04)

0.003

1.02 (1.00-1.04)

0.03

Female sex

55 (48.7)

234 (54.2)

0.80 (0.53-1.22)

0.30

1.00 (0.58-1.71)

0.99

Obesity

42 (37.2)

106 (24.5)

1.82 (1.17-2.82)

0.008

1.49 (0.85-2.62)

0.16

Diabetes mellitus

24 (21.2)

116 (26.9)

0.74 (0.45-1.21)

0.23

  

Chronic obstructive pulmonary disease

20 (17.7)

75 (17.4)

1.02 (0.60-1.76)

0.93

  

Alcohol abuse

9 (8.0)

64 (14.8)

0.50 (0.24-1.03)

0.06

0.77 (0.34-1.75)

0.54

Chronic kidney disease

15 (13.3)

33 (7.6)

1.85 (0.97-3.54)

0.06

1.35 (0.50-3.61)

0.55

Day 1 support, physiology, and laboratory parameters

APACHE II (n = 497, 101, 396)

25.0 (10.2)

20.0 (8.6)

1.06 (1.04-1.09)

<0.0001

1.05 (1.01-1.08)

0.006

Invasive mechanical ventilation (n = 537, 111, 426)

82 (73.9)

289 (67.8)

1.34 (0.84-2.14)

0.22

  

Inotrope or vasopressor

52 (46.0)

186 (43.1)

1.13 (0.74-1.71)

0.57

  

Mean arterial pressure (mmHg) (n = 506, 103, 403)

75.1 (20.9)

74.2 (18.6)

1.02 (0.91-1.14)

0.70

  

PaO2/FiO2 (n = 480, 101, 379)

126 (84)

161 (99)

0.95 (0.93-0.98)

0.002

0.95 (0.92-0.99)

0.007

Creatinine (μmol/L) (n = 521, 109, 412)

159 (127)

115 (118)

1.03 (1.01-1.04)

0.002

1.001 (0.98-1.03)

0.95

Platelets (109/L) (n = 504, 105, 399)

151 (93)

196 (91)

0.94 (0.91-0.97)

<0.0001

0.92 (0.89-0.96)

<0.0001

Other

Acute kidney injury

85 (75.2)

244 (56.5)

2.34 (1.47-3.73)

0.0004

1.35 (0.74-2.48)

0.33

  1. Categorical data are presented as n (%) and continuous data as mean (SD). Mortality status was missing for 17 patients. Heart rate, temperature, creatine kinase, WBC, albumin, urea, and urine output were excluded due to a high proportion of missing data. SOFA score was excluded because it was highly collinear with APACHE II (Pearson r = 0.6). For each variable, we specify n when it differs from the first row total. The final model included 414 patients and did not have evidence of lack of goodness of fit (p = 0.49). ORs for continuous variables refer to an increment of 1 unit (age, APACHE II) or 10 units (mean arterial pressure, PaO2/FiO2, platelets, creatinine).
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