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Table 1 Baseline characteristics by risk group

From: Diabetic nephropathy in a sibling and albuminuria predict early GFR decline: a prospective cohort study

 

High risk

Low risk

p-value

N

435

400

 

Gender (% female)

62.8

67.0

0.20

Age (yr)

58.9 ± 10.5

59.9 ± 11.8

0.20

Race (% AA)

51.4

52.5

0.75

Diabetes duration (yr)

14.1 ± 9.7

17.2 ± 8.7

< 0.01

HbA1c (%)

7.7 ± 1.9

7.8 ± 2.0

0.46

Systolic BP (mm Hg)

135.4 ± 17.8

134.2 ± 19.7

0.36

Diastolic BP (mm Hg)

75.9 ± 11.6

74.7 ± 11.9

0.14

Serum creatinine (mg/dl)

1.05 ± 0.37

0.97 ± 0.25

<0.01

eGFR creat (ml/min/1.73 m 2 )

74.3 ± 27.7

76.1 ± 24.3

0.32

Serum cystatin C (mg/dl)

1.1 ± 0.3

1.0 ± 0.5

<0.01

eGFR creat+cysC (ml/min/1.73 m 2 )

73.9 ± 29.3

77.4 ± 24.1

0.06

Urine alb:creat (mg/g)

27.6 (9-119)

11.2 (6-22)

<0.01

BP meds (%)

77.7

81.6

0.16

ACE inhibitor (%)

48.5

52.8

0.21

ARB (%)

14.1

14.8

0.77

Other BP meds (%)

57.3

57.4

0.98

Insulin (%)

45.8

42.9

0.26

Oral hypoglycemic agents (%)

61.0

65.6

0.06

Lipid-lowering agents (%)

64.2

70.2

0.01

  1. Data are presented as mean ± standard deviation for continuous measures, % frequency of reference level for discrete measures and median (first quartile-third quartile) for urine alb:creat (mg/g). Analyses to generate p-values include t-tests, χ2 tests and Wilcoxon rank-sum tests where appropriate. Abbreviations: ACE, angiotensin converting enzyme; alb:creat, albumin to creatinine ratio; ARB, angiotensin receptor blocker; BP, blood pressure; GFR, glomerular filtration rate; HbA1c, hemoglobin A1c.