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Table 2 Baseline characteristics of patients in each histopathological class

From: Validation of a newly proposed histopathological classification in Japanese patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

  Focal Crescentic Mixed Sclerotic pvalue
Age (years) 66.1 ± 11.4 66.3 ± 12.5 66.7 ± 10.2 67.5 ± 8.6 n.s.
Male/female, n 24/22 15/17 10/8 5/1 n.s.
MPO-ANCA, n 40 26 15 5 n.s.
PR3-ANCA, n 3 2 0 0  
Both negative, n 3 4 3 1  
eGFR (ml/min/1.73 m2) 38.1 (22.5–57.4) 12.0 (7.1–19.7) 16.5 (8.7–31.6) 12.4 (9.8–27.4) <0.0001
Serum albumin (g/dl) 3.4 (2.8–3.7) 2.7 (2.4–3.3) 3.1 (2.8–3.7) 3.8 (3.5–3.9) <0.01
Serum CRP (mg/dl) 4.13 (1.43–9.62) 4.98 (1.65–14.0) 1.21 (0.10–3.93) 0.16 (0.10–1.10) <0.001
Proteinuria (g/day) 0.35 (0.21–0.79) 1.50 (1.04–2.50) 1.75 (1.07–2.20) 1.50 (0.25–3.98) <0.0001
Immunosuppressants, yes/no, n 25/21 17/15 4/14 1/5 <0.05
Histopathological findings      
Normal glomeruli (%) 73.2 (60.0–81.6) 17.9 (10.6–28.0) 35.4 (22.5–43.8) 11.3 (0–22.0) <0.0001
Crescentic glomeruli (%) 13.8 (8.9–23.6) 67.7 (60.0–74.7) 31.4 (15.6–40.4) 12.4 (3.3–22.4) <0.0001
Globally sclerotic glomeruli (%) 6.5 (0–13.4) 3.2 (0–13.1) 29.3 (19.0–40.4) 64.5 (54.9–71.1) <0.0001
  1. Data are expressed as mean ± SD or median (interquartile range).
  2. Abbreviations: ns not significant, eGFR estimated glomerular filtration rate, MPO myeloperoxidase, PR3 proteinase-3, CRP C-reactive protein Immunosuppressants were administered after the diagnosis of ANCA-associated glomerulonephritis.
  3. eGFR: focal vs. crescentic***, focal vs. mixed**, focal vs. sclerotic*, Serum albumin: focal vs. crescentic*, crescentic vs. sclerotic**, Serum CRP: focal vs. mixed*, focal vs. sclerotic*, crescentic vs. mixed*, crescentic vs. sclerotic**, Proteinuria: focal vs. crescentic***, focal vs. mixed**, Immunosuppressants: focal vs. mixed*, crescentic vs. mixed*, Normal glomeruli: focal vs. crescentic***, focal vs. mixed***, focal vs. sclerotic***, Sclerotic glomeruli: focal vs. crescentic***, crescentic vs. mixed***, crescentic vs. sclerotic***, Globally sclerotic glomeruli: focal vs. mixed***, focal vs. sclerotic***, crescentic vs. mixed***, crescentic vs. sclerotic***, *p < 0.05, **p < 0.01, ***p < 0.001.