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Table 1 Genes included within the analysis on the basis of significant association (P < 0.05) within the GENIE meta-analysis[22] and demonstrating a consistent direction of effect across all four cohorts

From: Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy

Chromosome Position Gene SNP Direction Allele P-value
2 219395841 WNT6 rs6436094 - + ?? A 0.19
2 219411542 WNT6 rs730947 - + −+ A 0.12
2 219427976 WNT6 rs7596898 ?-?? T 0.73
2 219428221 WNT6 rs940469 + − ++ T 0.11
2 219429434 WNT6 rs11695967 + − ++ T 0.11
2 219434742 WNT6 rs10193725 - + −− T 0.18
2 219440386 WNT6 rs6754599 - + −+ C 0.36
2 219452118 WNT6 rs3806557 +−−- A 0.95
2 219454805 WNT6 rs10177996 -+++ T 0.95
2 219458990 WNT6 rs2385199 -+++ A 0.94
2 219464627 WNT6 rs7349332 ++−− T 0.61
3 41205327 CTNNB1 rs2691678 -- + − A 0.32
3 41205658 CTNNB1 rs7630377 -- + − T 0.58
3 41209520 CTNNB1 rs9859392 ++ − + C 0.39
3 41215181 CTNNB1 rs3864004 ---- A 0.38
3 41218746 CTNNB1 rs3915129 ++++ T 0.38
3 41229650 CTNNB1 rs2140090 ---- T 0.38
3 41236983 CTNNB1 rs1798802 -- + − A 0.59
3 41237448 CTNNB1 rs13072632 ++++ T 0.38
3 41243358 CTNNB1 rs11564447 + − +− T 0.41
3 41247085 CTNNB1 rs1880481 ---- A 0.37
3 41249076 CTNNB1 rs11564450 ++++ C 0.37
3 41254444 CTNNB1 rs4135385 +−−+ A 0.48
3 41259540 CTNNB1 rs9883073 -- + − A 0.41
3 41262022 CTNNB1 rs11711946 ++ − + T 0.41
3 41270771 CTNNB1 rs11129896 ++++ T 0.20
3 55450313 WNT5A rs815533 -++− A 0.73
3 55456115 WNT5A rs3913369 - + −− T 0.10
3 55462468 WNT5A rs751194 -- + − A 0.15
3 55464838 WNT5A rs1499890 -- + − A 0.15
3 55466053 WNT5A rs629537 +−−- A 0.82
3 55466476 WNT5A rs503022 +−−- A 0.76
3 55467366 WNT5A rs645486 + − +− A 0.46
3 55468554 WNT5A rs476986 --++ A 0.47
3 55469119 WNT5A rs6792802 -- + − T 0.07
3 55471300 WNT5A rs11706227 + − ++ T 0.07
3 55472993 WNT5A rs11710229 - + −− A 0.06
3 55474704 WNT5A rs12497254 -- + − A 0.08
3 55475448 WNT5A rs10865994 -- + − A 0.07
3 55476215 WNT5A rs1829556 ++ − + T 0.08
3 55482321 WNT5A rs556874 -++− T 0.13
3 55486715 WNT5A rs472631 +−−- A 0.73
3 55494897 WNT5A rs648872 + − ++ A 0.77
3 55495818 WNT5A rs566926 + − ++ T 0.59
3 55506307 WNT5A rs557077 +−−- A 0.63
3 55506999 WNT5A rs1160047 ---+ A 0.39
3 121176301 GSK3B rs6771023 ++++ T 0.05
3 121225411 GSK3B rs6770314 ---- A 0.04
3 121232101 GSK3B rs9851174 ---- A 0.04
3 121246776 GSK3B rs7652172 ---- T 0.04
3 121255730 GSK3B rs968824 ++++ A 0.04
3 121273402 GSK3B rs334536 ++++ A 0.05
3 121274994 GSK3B rs334535 ---- T 0.05
3 121292295 GSK3B rs334559 ---- A 0.05
4 108110470 DKK2 rs17509845 ++++ A 0.01
7 120715028 WNT16 rs2952556 ---- A <0.01
7 120723242 WNT16 rs10241888 ---- A <0.01
7 120727672 WNT16 rs2707521 ---- T 0.01
7 120732453 WNT16 rs1547960 ++++ A <0.01
7 120739818 WNT16 rs10231005 ---- A <0.01
14 58700292 DAAM1 rs6573249 ---- T 0.04
14 58728544 DAAM1 rs1252906 ++++ A 0.02
14 58735687 DAAM1 rs8016570 ++++ T 0.03
14 58744616 DAAM1 rs2146009 ++++ A 0.01
14 58748939 DAAM1 rs1252989 ++++ A 0.01
14 58753987 DAAM1 rs1270988 ++++ A 0.01
14 58795556 DAAM1 rs17095967 ++++ A 0.02
14 58800998 DAAM1 rs1253005 ---- T 0.04
14 58847352 DAAM1 rs7149497 ---- A 0.02
14 58870553 DAAM1 rs1957409 ---- A 0.03
16 312598 AXIN1 rs3916990 ++++ A 0.03
16 68144622 NFAT5 rs17230557 ++++ T 0.02
16 68184592 NFAT5 rs17231138 ++++ A 0.01
16 68198345 NFAT5 rs17297088 ---- T 0.02
16 68200854 NFAT5 rs17297207 ++++ A 0.02
16 68207765 NFAT5 rs17231474 ++++ A 0.02
16 68224440 NFAT5 rs6499238 ---- T 0.02
16 68262239 NFAT5 rs1437137 ---- A 0.02
16 68309874 NFAT5 rs689453 ---- T 0.02
17 42221887 WNT3 rs199496 ++++ A 0.01
17 42223260 WNT3 rs11655598 ++++ C 0.05
17 42223596 WNT3 rs199495 ---- A 0.02
17 42229159 WNT3 rs11650531 ++++ T 0.04
19 51811750 CALM3 rs11083840 ++++ T 0.03
  1. Direction of effect represents that observed in the FinnDiane, UK-ROI, US GoKinD George Washington University, US GoKinD Joslin Diabetes Center.? signifies where a marker failed QC in the original collection and was therefore unavailable for meta-analysis.
  2. The P value presented represents the association of the meta-analysed data from all four GENIE cohorts.