Table 3 Minor allele frequencies, genotype counts and logistic regression model adjusted for collection centre, gender, duration of type 1 diabetes, and average HbA1c

2

219428221

WNT6

rs940469

[T/C]

24/170/483

0.16

24/170/483

0.18

0.86

0.67 - 1.11

0.25

2

219430908

WNT6

rs690877

[T/C]

56/276/360

0.28

56/276/360

0.27

0.92

0.74 - 1.14

0.43

2

219440386

WNT6

rs6754599

[G/C]

18/166/494

0.15

18/166/494

0.17

0.85

0.65 - 1.11

0.22

2

219458990

WNT6

rs2385199

[G/A]

23/200/471

0.18

23/200/471

0.19

0.90

0.7 - 1.16

0.43

3

41205327

CTNNB1

rs2691678

[C/T]

51/250/390

0.25

51/250/390

0.25

1.01

0.81 - 1.26

0.91

3

41243358

CTNNB1

rs11564447

[G/T]

1/59/634

0.04

1/59/634

0.04

0.91

0.57 - 1.43

0.68

3

41254444

CTNNB1

rs4135385

[G/A]

49/237/398

0.24

49/237/398

0.23

1.04

0.84 - 1.3

0.70

3

55450313

WNT5A

rs815533

[A/G]

22/206/466

0.18

22/206/466

0.17

1.27

0.99 - 1.64

0.06

3

55456115

WNT5A

rs3913369

[T/G]

33/261/394

0.24

33/261/394

0.23

0.91

0.72 - 1.14

0.40

3

55466053

WNT5A

rs629537

[A/G]

11/145/534

0.12

11/145/534

0.13

0.89

0.67 - 1.18

0.40

3

55467090

WNT5A

rs845542

[C/T]

44/272/377

0.26

44/272/377

0.25

1.19

0.95 - 1.49

0.13

3

55494897

WNT5A

rs648872

[T/C]

13/172/501

0.14

13/172/501

0.17

0.86

0.67 - 1.1

0.22

3

55495818

WNT5A

rs566926

[T/G]

49/252/368

0.26

49/252/368

0.27

0.99

0.8 - 1.24

0.96

3

121016036

GSK3B

rs11917714

[T/C]

19/205/470

0.18

19/205/470

0.16

1.02

0.79 - 1.31

0.89

3

121018485

GSK3B

rs11929668

[G/C]

22/170/501

0.15

22/170/501

0.18

0.87

0.67 - 1.12

0.27

3

121133839

GSK3B

rs17204365

[C/T]

2/41/648

0.03

2/41/648

0.03

1.61

0.91 - 2.85

0.10

3

121157741

GSK3B

rs17810235

[T/C]

74/303/312

0.33

74/303/312

0.29

1.33

1.09 - 1.64

0.01

3

121300363

GSK3B

rs17471

[A/T]

3/110/581

0.08

3/110/581

0.09

0.67

0.47 - 0.95

0.02

3

121306727

GSK3B

rs11927974

[A/G]

8/101/584

0.08

8/101/584

0.09

0.98

0.71 - 1.35

0.89

3

121307901

GSK3B

rs334538

[A/G]

22/191/481

0.17

22/191/481

0.19

0.89

0.7 - 1.14

0.35

3

121308854

GSK3B

rs12053912

[T/A]

17/186/485

0.16

17/186/485

0.14

1.21

0.92 - 1.58

0.18

3

121315311

GSK3B

rs334543

[C/A]

66/311/307

0.32

66/311/307

0.35

0.79

0.65 - 0.97

0.02

4

108055760

DKK2

rs429941

[G/A]

53/282/356

0.28

53/282/356

0.28

1.08

0.88 - 1.34

0.46

4

108062942

DKK2

rs10488898

[A/G]

2/77/603

0.06

2/77/603

0.07

0.85

0.58 - 1.24

0.40

4

108065243

DKK2

rs17037102

[A/G]

7/132/526

0.11

7/132/526

0.10

1.17

0.85 - 1.6

0.34

4

108084260

DKK2

rs10488899

[G/T]

42/237/410

0.23

42/237/410

0.21

1.10

0.88 - 1.39

0.40

4

108110470

DKK2

rs17509845

[A/G]

1/66/622

0.05

1/66/622

0.05

1.08

0.69 - 1.7

0.74

4

108120464

DKK2

rs17618172

[G/A]

20/219/445

0.19

20/219/445

0.20

1.01

0.79 - 1.28

0.96

4

108135958

DKK2

rs7690634

[A/T]

9/165/515

0.13

9/165/515

0.12

1.19

0.89 - 1.58

0.24

4

108165736

DKK2

rs4956277

[C/A]

30/246/396

0.23

30/246/396

0.24

0.94

0.75 - 1.17

0.58

4

108170809

DKK2

rs10021344

[G/A]

150/357/185

0.47

150/357/185

0.48

0.99

0.82 - 1.19

0.88

4

108173328

DKK2

rs956137

[A/C]

4/111/577

0.09

4/111/577

0.08

1.28

0.92 - 1.8

0.15

4

108173463

DKK2

rs6827902

[C/A]

28/237/416

0.22

28/237/416

0.21

1.15

0.91 - 1.45

0.23

4

108181414

DKK2

rs6823507

[C/T]

1/88/593

0.07

1/88/593

0.08

0.87

0.6 - 1.26

0.46

4

108185493

DKK2

rs419178

[C/T]

38/272/379

0.25

38/272/379

0.27

0.86

0.69 - 1.07

0.17

4

108199999

DKK2

rs398093

[T/C]

12/138/510

0.12

12/138/510

0.12

1.09

0.81 - 1.46

0.58

4

108200154

DKK2

rs17510191

[C/T]

20/251/423

0.21

20/251/423

0.18

1.13

0.89 - 1.43

0.31

7

120727672

WNT16

rs2707521

[T/C]

103/338/239

0.40

103/338/239

0.41

0.90

0.74 - 1.1

0.32

7

120738146

WNT16

rs13247600

[C/G]

3/81/610

0.06

3/81/610

0.07

1.08

0.74 - 1.57

0.69

7

120738380

WNT16

rs2707520

[G/T]

166/340/183

0.49

166/340/183

0.49

1.12

0.92 - 1.35

0.25

7

120741508

WNT16

rs983926

[A/G]

6/101/587

0.08

6/101/587

0.09

0.93

0.67 - 1.3

0.68

7

120751201

WNT16

rs3757552

[C/T]

9/151/534

0.12

9/151/534

0.12

0.89

0.67 - 1.19

0.44

7

120762001

WNT16

rs3801387

[C/T]

69/283/340

0.30

69/283/340

0.29

1.00

0.81 - 1.23

0.99

7

120774586

WNT16

rs2707461

[T/C]

18/187/489

0.16

18/187/489

0.17

0.98

0.77 - 1.26

0.89

14

58696138

DAAM1

rs8016068

[T/C]

4/176/514

0.13

4/176/514

0.12

1.09

0.81 - 1.47

0.57

14

58713714

DAAM1

rs17095819

[G/A]

15/185/477

0.16

15/185/477

0.13

1.28

0.96 - 1.71

0.09

14

58728544

DAAM1

rs1252906

[G/T]

19/164/511

0.15

19/164/511

0.18

0.75

0.58 - 0.97

0.03

14

58826755

DAAM1

rs7155987

[T/C]

18/180/496

0.16

18/180/496

0.14

1.10

0.84 - 1.44

0.48

14

58833620

DAAM1

rs12878138

[T/C]

2/99/593

0.07

2/99/593

0.07

0.96

0.67 - 1.39

0.84

14

58861382

DAAM1

rs941882

[C/A]

40/238/416

0.23

40/238/416

0.23

1.03

0.82 - 1.28

0.82

14

58885779

DAAM1

rs17834014

[G/A]

3/86/605

0.07

3/86/605

0.08

0.97

0.67 - 1.42

0.88

14

58886484

DAAM1

rs12880248

[A/G]

12/177/505

0.14

12/177/505

0.14

1.06

0.8 - 1.39

0.70

14

58889427

DAAM1

rs12878070

[G/T]

150/334/210

0.46

150/334/210

0.42

1.10

0.91 - 1.32

0.33

14

58908520

DAAM1

rs17096179

[C/A]

5/104/585

0.08

5/104/585

0.09

0.88

0.63 - 1.24

0.47

14

58913159

DAAM1

rs1253192

[A/G]

5/80/609

0.06

5/80/609

0.09

0.65

0.46 - 0.93

0.02

16

275374

AXIN1

rs2685127

[T/C]

7/157/529

0.12

7/157/529

0.13

1.02

0.76 - 1.36

0.92

16

276397

AXIN1

rs400037

[T/C]

32/243/410

0.22

32/243/410

0.22

0.97

0.77 - 1.21

0.77

16

281080

AXIN1

rs12925669

[A/G]

22/171/501

0.15

22/171/501

0.16

1.06

0.82 - 1.37

0.65

16

289294

AXIN1

rs214246

[C/T]

148/349/196

0.47

148/349/196

0.49

0.93

0.77 - 1.12

0.45

16

303385

AXIN1

rs12930863

[C/T]

20/175/490

0.16

20/175/490

0.16

1.05

0.81 - 1.36

0.70

16

313818

AXIN1

rs11646942

[A/C]

51/261/355

0.27

51/261/355

0.31

0.89

0.72 - 1.1

0.29

16

333343

AXIN1

rs395901

[A/G]

7/115/569

0.09

7/115/569

0.09

0.82

0.6 - 1.14

0.24

16

336265

AXIN1

rs1805105

[A/G]

67/310/284

0.34

67/310/284

0.31

1.19

0.97 - 1.47

0.10

16

68112382

NFAT5

rs12921716

[A/G]

6/113/575

0.09

6/113/575

0.08

0.95

0.68 - 1.32

0.75

16

68117197

NFAT5

rs4783720

[C/T]

22/184/488

0.16

22/184/488

0.15

1.10

0.85 - 1.43

0.47

16

68200854

NFAT5

rs17297207

[G/A]

3/69/612

0.05

3/69/612

0.07

0.66

0.44 - 0.98

0.04

16

68203623

NFAT5

rs11639947

[T/C]

22/183/467

0.17

22/183/467

0.21

0.80

0.63 - 1.02

0.07

16

68281721

NFAT5

rs1064825

[A/G]

0/74/619

0.05

0/74/619

0.06

0.84

0.55 - 1.28

0.42

16

68290961

NFAT5

rs7359336

[G/A]

128/329/227

0.43

128/329/227

0.41

1.04

0.86 - 1.26

0.69

17

42163544

WNT3

rs35937770

[A/G]

83/321/283

0.35

83/321/283

0.35

0.99

0.81 - 1.21

0.90

17

42188384

WNT3

rs35732828

[A/C]

19/200/466

0.17

19/200/466

0.17

1.05

0.81 - 1.35

0.71

17

42209035

WNT3

rs199520

[G/A]

38/237/419

0.23

38/237/419

0.22

1.04

0.83 - 1.3

0.75

17

42221887

WNT3

rs199496

[A/G]

5/117/569

0.09

5/117/569

0.07

1.11

0.78 - 1.58

0.56

17

42221965

WNT3

rs11658976

[G/A]

129/338/227

0.43

129/338/227

0.42

1.03

0.85 - 1.25

0.74

17

42223260

WNT3

rs11655598

[G/C]

46/249/387

0.25

46/249/387

0.29

0.94

0.76 - 1.16

0.57

17

42223353

WNT3

rs12452064

[A/G]

147/322/211

0.45

147/322/211

0.43

1.08

0.9 - 1.3

0.42

17

42224733

WNT3

rs10432043

[T/C]

86/301/284

0.35

86/301/284

0.33

1.07

0.88 - 1.31

0.50

17

42234514

WNT3

rs7207916

[A/G]

113/313/267

0.39

113/313/267

0.43

0.93

0.77 - 1.12

0.43

17

42243374

WNT3

rs11079737

[A/G]

54/268/338

0.28

54/268/338

0.27

1.12

0.91 - 1.38

0.30

17

42259048

WNT3

rs11079738

[G/A]

143/362/188

0.47

143/362/188

0.47

1.02

0.84 - 1.23

0.88

17

42261948

WNT3

rs8069437

[T/C]

35/225/433

0.21

35/225/433

0.23

0.85

0.68 - 1.07

0.16

19

51775092

CALM3

rs8103534

[C/T]

63/298/333

0.31

63/298/333

0.31

0.96

0.78 - 1.18

0.67

19

51781925

CALM3

rs4274528

[T/C]

7/144/542

0.11

7/144/542

0.12

1.17

0.87 - 1.57

0.31

19

51790267

CALM3

rs7260181

[C/T]

146/355/193

0.47

146/355/193

0.46

1.08

0.89 - 1.31

0.43

19

51798474

CALM3

rs4380146

[G/T]

69/284/327

0.31

69/284/327

0.32

1.03

0.84 - 1.26

0.76

19

51800325

CALM3

rs11671131

[C/T]

12/167/513

0.14

12/167/513

0.14

0.87

0.67 - 1.14

0.32

19

51804580

CALM3

rs710889

[A/G]

94/315/285

0.36

94/315/285

0.36

0.93

0.76 - 1.13

0.47

19

51804978

CALM3

rs10405893

[A/G]

5/153/535

0.12

5/153/535

0.11

1.25

0.92 - 1.69

0.16

19

51811750

CALM3

rs11083840

[G/T]

118/341/235

0.42

118/341/235

0.44

0.91

0.75 - 1.1

0.32

19

51811873

CALM3

rs11083841

[G/A]

26/181/457

0.18

26/181/457

0.16

1.15

0.9 - 1.47

0.26