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Table 4 Most significant results from logistic regression analyses

From: Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy

a. Single SNP analysis for diabetic nephropathy

Gene

SNP

a OR

b C.I.

c P

GSK3B

rs17810235

1.23

1.03 - 1.45

0.022

NFAT5

rs11639947

0.79

0.64 - 0.97

0.023

AXIN1

rs11646942

0.82

0.68 - 0.97

0.026

DAAM1

rs17095819

1.27

1.01 - 1.59

0.045

DKK2

rs17510191

1.23

1.01 - 1.49

0.047

b. Adjusted logistic regression analysis for diabetic nephropathy

GSK3B

rs17810235

1.33

1.09 - 1.64

0.006

DAAM1

rs1253192

0.65

0.46 - 0.93

0.018

GSK3B

rs17471

0.67

0.47 - 0.95

0.025

GSK3B

rs334543

0.79

0.65 - 0.97

0.025

DAAM1

rs1252906

0.75

0.58 - 0.97

0.027

NFAT5

rs17297207

0.66

0.44 - 0.98

0.040

c. Adjusted logistic regression analysis for end-stage renal disease

WNT3

rs11079737

1.50

1.13 - 1.98

0.005

DAAM1

rs1253192

0.43

0.23 - 0.81

0.009

DAAM1

rs941882

1.45

1.08 - 1.94

0.013

CALM3

rs8103534

0.68

0.50 - 0.92

0.013

DKK2

rs6827902

1.47

1.08 - 1.99

0.015

DAAM1

rs1252906

0.60

0.40 - 0.91

0.015

WNT3

rs11079738

1.33

1.02 - 1.74

0.035

DAAM1

rs7155987

1.43

1.02 - 2.02

0.040

DAAM1

rs17834014

1.61

1.01 - 2.55

0.045

WNT6

rs940469

0.68

0.47 - 0.99

0.046

  1. aOR: Odds Ratio.
  2. bC.I.: 95% Confidence Intervals.
  3. cP: value adjusted for collection centre, gender, duration of type 1 diabetes, and average HbA1c as covariates; not corrected for multiple testing.