Figure 1

Pathologic findings in a patient with rifampin-associated acute tubulointerstitial nephritis and Fanconi syndrome. Light microscopy revealed the extensive mononuclear cell infiltrates including epithelioid histiocytes and eosinophils, mild interstitial fibrosis and tubular atrophy (A: original magnification X 100; B: original magnification x 400). Immunofluorescent stains showed focal granular deposits of immunoglobulin A (C) and complement 3 (D) in mesangial spaces and tubules. Subendothelial electron-dense deposits (E) and expanded mesangial spaces with electron dense deposits (F) were visible using electron microscopy.