Skip to main content

Table 1 Characteristics of study participants by levels of solutes

From: Retained organic solutes, patient characteristics and all-cause and cardiovascular mortality in hemodialysis: results from the retained organic solutes and clinical outcomes (ROSCO) investigators

Characteristic

Overall

P-cresol sulfate (mg/dl)

Indoxyl sulfate (mg/dl)

Monomethylamine (μg/l)

Dimethlyamine (μM)

  

Low

High

Low

High

Low

High

Low

High

  

0.0-3.l

3.1-11.1

0-1.6

1.6-6.8

24.2-49.6

49.7-190.6

7.6-18.3

18.3-33.9

N (%)

521 (100%)

261 (50.1)

260 (49.9)

261 (50.1)

260 (49.9)

262 (50.3)

259 (49.7)

263 (50.5)

258 (49.5)

Demographics

Mean age (SD)

58.3 (14.7)

56.6 (14.2)*

59.9 (14.9)*

57.3 (13.9)

59.2 (15.3)

56.9 (15.2)*

59.6 (14.0)*

58.6 (14.9)

57.9 (14.4)

% white

61.0

61.7

60.4

59.0

63.1

63.4

58.7

63.5

58.5

% male

54.1

47.1*

61.2*

54.4

53.9

50.0

58.3

53.6

54.7

Clinical

% ICED = 3

29.2

31.4

26.9

35.6*

22.7*

27.1

31.3

26.2

32.2

Mean BMI (SD)

27.4 (7.0)

28.3 (7.4)*

26.5 (6.5)*

27.7 (7.3)

27.1 (6.6)

27.5 (7.7)

27.3 (6.2)

27.1 (7.4)

27.8 (6.5)

% with residual urine output at 1 year

38.9

41.4

36.6

42.9

35.2

37.4

40.4

42.3

35.6

Mean KtV (SD)

1.27

1.26

1.29

1.24*

1.31*

1.27

1.27

1.27

1.27

Cause of ESRD

 Diabetes mellitus

47.8

50.2*

45.4*

56.7**

38.9**

49.2

46.3

46.4

49.2

 Hypertension

18.2

13.0*

23.5*

14.9**

21.5**

16.0

20.5

19.4

17.1

 Glomerulonephritis

16.1

18.4*

13.9*

10.3**

21.9**

14.5

17.8

15.2

17.1

 Other

17.9

18.4*

17.3*

18.0**

17.7**

20.2

15.4

15.2

17.1

% with diabetes

54.9

56.7

53.1

63.2**

46.5**

55.7

54.1

53.6

56.2

% with hypertension

97.0

96.5

97.6

96.6

97.5

97.5

96.6

96.5

97.6

% with gastrointestinal disease

41.8

44.8

38.9

43.3

40.4

39.7

44.0

42.6

41.1

Laboratory

Mean albumin (SD)

3.6 (0.4)

3.6 (0.4)*

3.7 (0.3)*

3.6 (0.4)**

3.7 (0.3)**

3.6 (0.4)*

3.7 (0.3)*

3.7 (0.3)

3.6 (0.4)

Mean creatinine (SD)

7.3 (2.4)

7.1 (2.5)

7.5 (2.3)

6.5 (2.1)**

8.1 (2.5)**

6.9 (2.4)**

7.8 (2.4)**

6.9 (2.4)**

7.7 (2.4)**

Median CRP (IQR)

0.4 (0.2-1.1)

0.4 (0.2-1.5)*

0.4 (0.2-0.8)*

0.5 (0.2-1.2)

0.4 (0.2-1.0)

0.4 (0.2-1.2)

0.4 (0.2-1.0)

0.4 (0.2-1.3)

0.4 (0.2-1.0)

  1. Low, below population median value for solute; high, at or above population median values for solute. Diabetes, hypertension, and gastrointestinal disease were defined by domains of the index of disease severity scale of the ICED. n = 521 for all variables except BMI (n = 492), albumin (n = 515), creatinine (n = 516), CRP (n = 517), Kt/V (n = 401) and residual urine output at 1 year (n = 447).
  2. *P < 0.05 for high vs. low level of solute, by ANOVA or χ2 test.
  3. **P < 0.001 for high vs. low level of solute, by ANOVA or χ2 test.
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us