Table 3 Relative hazards (95% CI) for all-cause mortality by solute
Solute | Overall (continuous, per 1 SD) | Hazard ratio (95% CI) | |||
|---|---|---|---|---|---|
Below median | Above median | ||||
P-cresol sulfate | |||||
Range of values | 0-11.1 mg/dl (SD = 1.76 mg/dl) | 0-3.1 mg/dl | 3.1-11.1 mg/dl | ||
Unadjusted | 1.05 (0.93-1.17) | Reference | 1.10 (0.88-1.37) | ||
Adjusted* | 1.02 (0.90-1.16) | Reference | 1.03 (0.81-1.31) | ||
+ obesity, creatinine | 1.02 (0.90-1.16) | Reference | 1.03 (0.83-1.28) | ||
Indoxyl sulfate | |||||
Range of values | 0-6.8 mg/dl (SD = 1.11 mg/dl) | 0-1.6 mg/dl | 1.6-6.8 mg/dl | ||
Unadjusted | 0.93 (0.84-1.04) | Reference | 1.03 (0.83-1.28) | ||
Adjusted* | 0.98 (0.87-1.10) | Reference | 1.14 (0.90-1.44) | ||
+ obesity, creatinine | 1.04 (0.91-1.18) | Reference | 1.30 (1.01-1.69) | ||
MMA | |||||
Range of values | 24.2-190.6 ug/L (SD = 16.48 ug/L) | 24.2-49.6 ug/L | 49.7-190.6 ug/L | ||
Unadjusted | 1.10 (0.99-1.23) | Reference | 1.01 (0.81-1.26) | ||
Adjusted* | 1.05 (0.94-1.17) | Reference | 0.94 (0.74-1.20) | ||
+ obesity, creatinine | 1.09 (0.97-1.22) | Reference | 1.00 (0.78-1.29) | ||
DMA | |||||
Range of values | 7.6-33.9 uM (SD = 3.69 uM) | 7.6-18.3 uM | 18.3-33.9 uM | ||
Unadjusted | 0.96 (0.86-1.07) | Reference | 0.86 (0.69-1.08) | ||
Adjusted* | 1.00 (0.89-1.12) | Reference | 0.88 (0.69-1.11) | ||
+ obesity, creatinine | 1.01 (0.90-1.14) | Reference | 0.91 (0.71-1.17) | ||
Total Score (vs. 0)** | Continuous | 1 | 2 | 3 | 4 |
Unadjusted | 1.00 (0.91-1.09) | 1.53 (1.03-2.27) | 1.24 (0.87-1.77) | 1.21 (0.83-1.77) | 1.14 (0.72-1.79) |
Adjusted* | 0.99 (0.89-1.10) | 1.28 (0.85-1.94) | 1.24 (0.85-1.80) | 0.96 (0.64-1.43) | 1.26 (0.78-2.04) |
+ obesity, creatinine | 1.04 (0.93-1.16) | 1.29 (0.84-1.99) | 1.28 (0.86-1.90) | 1.06 (0.69-1.64) | 1.49 (0.88-2.51) |