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Table 4 Relative hazards (95% CI) for cardiovascular mortality by solute

From: Retained organic solutes, patient characteristics and all-cause and cardiovascular mortality in hemodialysis: results from the retained organic solutes and clinical outcomes (ROSCO) investigators

Solute

Overall (continuous, per 1 SD)

Hazard ratio (95% CI)

  

Below median

Above median

P-cresol sulfate

Range of values

0-11.1 mg/dl (SD = 1.76 mg/dl)

0-3.1 mg/dl

3.1-11.1 mg/dl

Unadjusted

1.09 (0.93-1.28)

Reference

1.35 (0.98-1.85)

Adjusted*

1.06 (0.89-1.27)

Reference

1.24 (0.87-1.77)

+ obesity, creatinine

1.07 (0.88-1.29)

Reference

1.30 (0.89-1.89)

Indoxyl sulfate

Range of values

0-6.8 mg/dl (SD = 1.11 mg/dl)

0-1.6 mg/dl

1.6-6.8 mg/dl

Unadjusted

0.87 (0.74-1.03)

Reference

0.93 (0.67-1.27)

Adjusted*

0.88 (0.74-1.06)

Reference

0.93 (0.66-1.31)

+ obesity, creatinine

0.96 (0.79-1.18)

Reference

1.11 (0.76-1.64)

MMA

Range of values

24.2-190.6 ug/L (SD = 16.48 ug/L)

24.2-49.6 ug/L

49.7-190.6 ug/L

Unadjusted

1.06 (0.90-1.24)

Reference

0.99 (0.72-1.36)

Adjusted*

0.97 (0.82-1.15)

Reference

0.91 (0.64-1.29)

+ obesity, creatinine

1.06 (0.89-1.26)

Reference

1.01 (0.69-1.48)

DMA

Range of values

7.6-33.9 uM (SD = 3.69 uM)

7.6-18.3 uM

18.3-33.9 uM

Unadjusted

0.97 (0.83-1.14)

Reference

0.81 (0.58-1.13)

Adjusted*

1.00 (0.85-1.18)

Reference

0.84 (0.59-1.18)

+ obesity, creatinine

1.02 (0.86-1.22)

Reference

0.89 (0.61-1.29)

Total Score (vs. 0)**

Continuous

1

2

3

4

Unadjusted

1.00 (0.88-1.14)

1.22 (0.70-2.13)

1.00 (0.61-1.65)

0.78 (0.45-1.35)

1.43 (0.79-2.59)

Adjusted*

0.97 (0.84-1.13)

1.03 (0.57-1.84)

0.89 (0.52-1.51)

0.59 (0.33-1.07)

1.37 (0.73-2.58)

+ obesity, creatinine

1.05 (0.89-1.25)

1.11 (0.60-2.06)

0.97 (0.55-1.71)

0.72 (0.38-1.37)

1.91 (0.94-3.88)

  1. All models stratified by clinic cluster. *Adjustment: basic model, age at enrollment, sex, race, comorbidity score (ICED), and baseline albumin: + obesity and creatinine value. **Total number of solutes with levels above the population median.