Solute | Overall (continuous, per 1 SD) | Hazard ratio (95% CI) | |||
---|---|---|---|---|---|
Below median | Above median | ||||
P-cresol sulfate | |||||
Range of values | 0-11.1 mg/dl (SD = 1.76 mg/dl) | 0-3.1 mg/dl | 3.1-11.1 mg/dl | ||
Unadjusted | 1.09 (0.93-1.28) | Reference | 1.35 (0.98-1.85) | ||
Adjusted* | 1.06 (0.89-1.27) | Reference | 1.24 (0.87-1.77) | ||
+ obesity, creatinine | 1.07 (0.88-1.29) | Reference | 1.30 (0.89-1.89) | ||
Indoxyl sulfate | |||||
Range of values | 0-6.8 mg/dl (SD = 1.11 mg/dl) | 0-1.6 mg/dl | 1.6-6.8 mg/dl | ||
Unadjusted | 0.87 (0.74-1.03) | Reference | 0.93 (0.67-1.27) | ||
Adjusted* | 0.88 (0.74-1.06) | Reference | 0.93 (0.66-1.31) | ||
+ obesity, creatinine | 0.96 (0.79-1.18) | Reference | 1.11 (0.76-1.64) | ||
MMA | |||||
Range of values | 24.2-190.6 ug/L (SD = 16.48 ug/L) | 24.2-49.6 ug/L | 49.7-190.6 ug/L | ||
Unadjusted | 1.06 (0.90-1.24) | Reference | 0.99 (0.72-1.36) | ||
Adjusted* | 0.97 (0.82-1.15) | Reference | 0.91 (0.64-1.29) | ||
+ obesity, creatinine | 1.06 (0.89-1.26) | Reference | 1.01 (0.69-1.48) | ||
DMA | |||||
Range of values | 7.6-33.9 uM (SD = 3.69 uM) | 7.6-18.3 uM | 18.3-33.9 uM | ||
Unadjusted | 0.97 (0.83-1.14) | Reference | 0.81 (0.58-1.13) | ||
Adjusted* | 1.00 (0.85-1.18) | Reference | 0.84 (0.59-1.18) | ||
+ obesity, creatinine | 1.02 (0.86-1.22) | Reference | 0.89 (0.61-1.29) | ||
Total Score (vs. 0)** | Continuous | 1 | 2 | 3 | 4 |
Unadjusted | 1.00 (0.88-1.14) | 1.22 (0.70-2.13) | 1.00 (0.61-1.65) | 0.78 (0.45-1.35) | 1.43 (0.79-2.59) |
Adjusted* | 0.97 (0.84-1.13) | 1.03 (0.57-1.84) | 0.89 (0.52-1.51) | 0.59 (0.33-1.07) | 1.37 (0.73-2.58) |
+ obesity, creatinine | 1.05 (0.89-1.25) | 1.11 (0.60-2.06) | 0.97 (0.55-1.71) | 0.72 (0.38-1.37) | 1.91 (0.94-3.88) |