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Table 4 Mean urine NGAL concentrations before surgery (baseline), 3 hr, 6 hr, 12 hr, 18 hr, and 24 hr after operation for all patients and stratified by the presence of acute kidney injury

From: Prophylaxis with erythropoietin versus placebo reduces acute kidney injury and neutrophil gelatinase-associated lipocalin in patients undergoing cardiac surgery: a randomized, double-blind controlled trial

Urine NGAL (ng/ml)

Baseline

3 hr

6 hr

12 hr

18 hr

24 hr

All patients

Placebo group (n = 50)

61 ± 42

164 ± 144

174 ± 134

164 ± 113

137 ± 95

122 ± 87

rHuEPO group (n = 50)

55 ± 51

105 ± 76*

109 ± 64#

114 ± 67#

101 ± 62*

93 ± 56

Patients with acute kidney injury

Placebo group (n = 19)

65 ± 23

281 ± 151

296 ± 140

271 ± 81

207 ± 107

173 ± 105

rHuEPO group (n = 7)

62 ± 28

176 ± 41*

167 ± 40#

164 ± 57#

128 ± 55*

101 ± 52*

Patients without acute kidney injury

Placebo group (n = 31)

58 ± 50

99 ± 89

106 ± 66

104 ± 79

98 ± 60

94 ± 61

rHuEPO group (n = 43)

54 ± 54

93 ± 75

100 ± 64

106 ± 66

97 ± 64

92 ± 58

  1. Data are expressed as mean ± S.D.
  2. Significant differences by Bonferroni post-hoc test of ANOVA.
  3. *p < 0.05, #p < 0.01 compared between placebo and rHuEPO group.
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BMC Nephrology

ISSN: 1471-2369

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