From: Effect of treatment on urinary kidney injury molecule-1 in IgA nephropathy
Variable | Immunotherapy | No imunotherapy | P |
---|---|---|---|
Age (years) | 33.6 ± 18.32 | 40.06 ± 10.31 | 0.481 |
Male/Female {%} | 4/1 {80/20} | 15/17 {47/53} | <0.0001 |
Serum Creatinine (mg/dL) | 1.52 ± 0.55 | 1.20 ± 0.69 | 0.347 |
CKD EPI eGFR (ml/min/1.73 m2) | 70.06 ± 37.03 | 80.62 ± 29.90 | 0.505 |
24 hrs Urinary Protein (mg/day) | 4077.18 ± 3098.19 | 1000.63 ± 899.85 | <0.0001 |
Mean Blood Pressure, systolic (mm/Hg) | 128 ± 13 | 125 ± 14.14 | 0.693 |
Mean Blood Pressure, diastolic (mmHg) | 76 ± 8.3 | 78 ± 8.95 | 0.664 |
Mesagial hypercellularity (%) | 100 | 59.4 | <0.0001 |
Segmental glomerularsclerosis (%) | 100 | 90.7 | <0.0001 |
Endocapillary hypercellularity (%) | 80 | 31.3 | <0.0001 |
Tubular atrophy/interstitial fibrosis 1 (%) | 0 | 37.5 | <0.0001 |
Tubular atrophy/interstitial fibrosis 2 (%) | 60 | 15.7 | <0.0001 |
Baseline KIM-1/Cr (ng/mg) | 0.51 [0.31-1.23] | 1.12 [0.62-2.02] | 0.155 |
Follow-up KIM-1/Cr (ng/mg) | 0.52 [0.01-0.64] | 0.26 [0.13-0.73] | 0.625 |
Δ KIM-1/Cr (ng/mg) | 0.49 [0.34-0.71] | 0.81 [0.17-1.23] | 0.230 |
Baseline eGFR (ml/min/1.73 m2) | 70.65 ± 37.03 | 80.62 ± 29.9 | 0.505 |
Follow-up eGFR (ml/min/1.73 m2) | 72.82 ± 48.44* | 82.26 ± 30.03** | 0.552 |
Baseline proteinuria (mg/d) | 4855.1 [1569.7-5560.5] | 720 [401-1189.7] | |
Follow-up proteinuria (mg/d) | 1323.9 [374.6-1480] | 545.6 [250.5-824] | |
P | 0.273 | 0.077 |