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Table 2 Effect of paricalcitol on calcium metabolism, blood pressure and 24-h albumin excretion in patients with stage III-IV CKD and albuminuria (n = 26)

From: Effect of paricalcitol on renin and albuminuria in non-diabetic stage III-IV chronic kidney disease: a randomized placebo-controlled trial

  Placebo Paricalcitol P value
Calcium and phosphate metabolism
p-iPTH (pmol/l) 11.80 [8.82;14.93] 6.44 [3.11;8.78] <0.001
p-Ca++ (mmol/l) 1.22 [1.16;1.25] 1.23 [1.19;1.28] 0.01
p-phosphate (mmol/l) 1.18 [0.97;1.35] 1.29 [1.10;1.59] 0.02
p-ALP (U/l) 66 [58;91] 65 [51;82] <0.001
p-25(OH)D (nmol/l) 58 [39;72] 59 [50;69] 0.26
p-FGF23 (pg/ml) 28.5 [19.7;46.7] 32.3 [27.2;67.1] 0.002
u-Ca (mmol/24-h) 0.78 [0.39;2.03] 1.24 [0.66;3.04] 0.006
u-Ca/cr (mmol/mmol) 0.06 [0.03;0.15] 0.12 [0.06;0.22] 0.005
24-h ambulatory blood pressure and arterial stiffness
24-h SBP (mmHg) 133 ± 11 133 ± 10 0.92
24-h DBP (mmHg) 81 ± 7 81 ± 7 0.94
24-h heart rate (bpm) 67 ± 9 68 ± 9 0.15
PWV (m/s) 7.9 ± 1.3 7.6 ± 1.3 0.21
AIx@75 (%) 21 ± 13 19 ± 11 0.30
Central SBP (mmHg) 132 ± 12 130 ± 13 0.34
Central DBP (mmHg) 82 ± 7 82 ± 6 0.97
Creatinine clearance and albumin excretion in 24-h urine
Urine output (ml/24-h) 2805 [2430;3160] 2794 [2270;3210] 0.43
Creatinine clearance (ml/min/1.73 m2) 36 [28;51] 32 [27;46] 0.005
u-alb (mg/24-h) 665 [80;2598] 590 [146;2025] 0.12
UACR (mg/g) 507 [80;1523] 388 [104;1109] 0.34
  1. Values are presented as medians with 25 and 75 percentiles in brackets, or as means ± SD. iPTH Intact parathyroid hormone, Ca ++ Ionized calcium, ALP Alkaline phosphatase 25(OH)D, 25-hydroxyvitamin D; FGF23, fibroblast growth factor 23; u-Ca/cr, urinary calcium-creatinine ratio; PWV, carotid-femoral pulse wave velocity; AIx@75, central augmentation index standardized to a heart rate of 75 beats per minute (bpm); UACR, urinary albumin-creatinine ratio. P values represent the probability of a difference between treatments.