Table 2 Effect of paricalcitol on calcium metabolism, blood pressure and 24-h albumin excretion in patients with stage III-IV CKD and albuminuria (n = 26)

Calcium and phosphate metabolism

p-iPTH (pmol/l)

11.80 [8.82;14.93]

6.44 [3.11;8.78]

<0.001

p-Ca⁺⁺ (mmol/l)

1.22 [1.16;1.25]

1.23 [1.19;1.28]

0.01

p-phosphate (mmol/l)

1.18 [0.97;1.35]

1.29 [1.10;1.59]

0.02

p-ALP (U/l)

66 [58;91]

65 [51;82]

<0.001

p-25(OH)D (nmol/l)

58 [39;72]

59 [50;69]

0.26

p-FGF23 (pg/ml)

28.5 [19.7;46.7]

32.3 [27.2;67.1]

0.002

u-Ca (mmol/24-h)

0.78 [0.39;2.03]

1.24 [0.66;3.04]

0.006

u-Ca/cr (mmol/mmol)

0.06 [0.03;0.15]

0.12 [0.06;0.22]

0.005

24-h ambulatory blood pressure and arterial stiffness

24-h SBP (mmHg)

133 ± 11

133 ± 10

0.92

24-h DBP (mmHg)

81 ± 7

81 ± 7

0.94

24-h heart rate (bpm)

67 ± 9

68 ± 9

0.15

PWV (m/s)

7.9 ± 1.3

7.6 ± 1.3

0.21

AIx@75 (%)

21 ± 13

19 ± 11

0.30

Central SBP (mmHg)

132 ± 12

130 ± 13

0.34

Central DBP (mmHg)

82 ± 7

82 ± 6

0.97

Creatinine clearance and albumin excretion in 24-h urine

Urine output (ml/24-h)

2805 [2430;3160]

2794 [2270;3210]

0.43

Creatinine clearance (ml/min/1.73 m²)

36 [28;51]

32 [27;46]

0.005

u-alb (mg/24-h)

665 [80;2598]

590 [146;2025]

0.12

UACR (mg/g)

507 [80;1523]

388 [104;1109]

0.34