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Figure 2 | BMC Nephrology

Figure 2

From: Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease

Figure 2

Changes in pro-inflammatory lipoxygenases-mediated linoleic acid metabolites 9-HODE and 13-HODE in (A) plasma and (B) kidney tissue of healthy (+/+) and Cy/+ rats. Cy/+ rats were additionally treated with 4 mg/kg/day lovastatin for 5 weeks. 9-HODE is mainly produced by 5-LOX, 13-HODE by 15-LOX. *p < 0.05 vs Cy/+ plus lovastatin, **p < 0.01 vs. +/+,***p < 0.001 vs. +/+; n = 5-15.

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