Figure 3
Changes in pro-inflammatory arachidonic acid metabolites 8-HETE, 9-HETE and 12-HETE in (A) plasma and (B) kidney tissue of healthy (+/+) and cystic Cy/+ rats. Cy/+ rats were additionally treated with 4 mg/kg/day lovastatin for 5 weeks. 8-HETE and 9-HETE are mainly produced by 8- and 9-LOX, 12-HETE by 12-LOX. Significance levels are given for Cy/+ control versus +/+ control and Cy/+ plus lovastatin versus Cy/+ control: *p < 0.05 vs. +/+, **p < 0.01 vs. Cy/+ lovastatin; n = 5-15.