|
Metabolite
|
+/+
|
Cy/+
|
Cy/+ plus lovastatin
|
|---|
|
Acetate [nmol/g]
|
553.6 ± 288.8
|
229.7 ± 139.3*
|
272.2 ± 70.5
|
|
Alanine [nmol/g]
|
1309.8 ± 300.6
|
1117.2 ± 412.1
|
938.3 ± 324.4
|
|
Allantoin [nmol/g]
|
623.2 ± 237.7
|
1572.1 ± 257.1**
|
1150.1 ± 227.4*
|
|
Aspartate [nmol/g]
|
584.0 ± 98.2
|
381.1 ± 30.5*
|
572.7 ± 75.9**
|
|
Citrate [nmol/g]
|
1366.9 ± 296.8
|
919.3 ± 150.7*
|
1419.2 ± 92.2**
|
|
Glucose [nmol/g]
|
1145.5 ± 237.9
|
806.5 ± 113.2*
|
674.1 ± 104.6*
|
|
Glutamate [nmol/g]
|
4615.0 ± 461.6
|
3669.4 ± 806.1*
|
3690.8 ± 933.9
|
|
Glutamine [nmol/g]
|
1437.1 ± 724.0
|
1385.9 ± 303.4
|
1087.4 ± 425.7
|
|
Glycine [nmol/g]
|
4763.2 ± 2284.7
|
3173.1 ± 391.1
|
4999.2 ± 2408.0
|
|
GPC [nmol/g]
|
696.9.3 ± 48.2
|
541.8 ± 122.2*
|
631.3 ± 222.5
|
|
3-Hydroxybutyrate [nmol/g]
|
442.7 ± 118.8
|
301.2 ± 43.8*
|
335.4 ± 97.6
|
|
Lactate [nmol/g]
|
4480.7 ± 1303.0
|
4729.8 ± 696.7
|
5876.9 ± 393.5*
|
|
Myo-inositol [nmol/g]
|
8170.4 ± 1606.9
|
8789.3 ± 2184.8
|
9258.2 ± 2478.2
|
|
Succinate [nmol/g]
|
3353.4 ± 278.2
|
2219.6 ± 557.0**
|
2160.9 ± 420.3
|
|
Taurine [μmol/g]
|
12.0 ± 3.7
|
11.5 ± 1.6
|
11.7 ± 2.4
|
|
TAG/DAG [μmol/g]
|
8.5 ± 2.2
|
5.1 ± 0.8*
|
5.9 ± 2.2
|
|
Δ-2 PUFA [μmol/g]
|
12.1 ± 2.2
|
8.0 ± 0.7*
|
10.0 ± 2.4
|
|
Cholines [μmol/g]
|
1.8 ± 0.5
|
1.3 ± 0.1
|
1.6 ± 0.2*
|
- Values are presented as means ± standard deviations (n = 4-5). Significance levels are given for Cy/+ versus +/+ animals and Cy/+ plus lovastatin versus Cy/+ animals: *p < 0.05, **p < 0.01; as determined by ANOVA (with post-hoc pairwise multiple comparison Tukey-test). Abbreviations: DAG: diacylglycerol, GPC: glycerophosphocholine, PUFA: polyunsaturated fatty acids, TAG: triacylglycerol.
