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Table 1 Concentration of water-soluble and lipid metabolites as calculated from rat kidney tissue samples using 1 H-NMR

From: Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease

Metabolite +/+ Cy/+ Cy/+ plus lovastatin
Acetate [nmol/g] 553.6 ± 288.8 229.7 ± 139.3* 272.2 ± 70.5
Alanine [nmol/g] 1309.8 ± 300.6 1117.2 ± 412.1 938.3 ± 324.4
Allantoin [nmol/g] 623.2 ± 237.7 1572.1 ± 257.1** 1150.1 ± 227.4*
Aspartate [nmol/g] 584.0 ± 98.2 381.1 ± 30.5* 572.7 ± 75.9**
Citrate [nmol/g] 1366.9 ± 296.8 919.3 ± 150.7* 1419.2 ± 92.2**
Glucose [nmol/g] 1145.5 ± 237.9 806.5 ± 113.2* 674.1 ± 104.6*
Glutamate [nmol/g] 4615.0 ± 461.6 3669.4 ± 806.1* 3690.8 ± 933.9
Glutamine [nmol/g] 1437.1 ± 724.0 1385.9 ± 303.4 1087.4 ± 425.7
Glycine [nmol/g] 4763.2 ± 2284.7 3173.1 ± 391.1 4999.2 ± 2408.0
GPC [nmol/g] 696.9.3 ± 48.2 541.8 ± 122.2* 631.3 ± 222.5
3-Hydroxybutyrate [nmol/g] 442.7 ± 118.8 301.2 ± 43.8* 335.4 ± 97.6
Lactate [nmol/g] 4480.7 ± 1303.0 4729.8 ± 696.7 5876.9 ± 393.5*
Myo-inositol [nmol/g] 8170.4 ± 1606.9 8789.3 ± 2184.8 9258.2 ± 2478.2
Succinate [nmol/g] 3353.4 ± 278.2 2219.6 ± 557.0** 2160.9 ± 420.3
Taurine [μmol/g] 12.0 ± 3.7 11.5 ± 1.6 11.7 ± 2.4
TAG/DAG [μmol/g] 8.5 ± 2.2 5.1 ± 0.8* 5.9 ± 2.2
Δ-2 PUFA [μmol/g] 12.1 ± 2.2 8.0 ± 0.7* 10.0 ± 2.4
Cholines [μmol/g] 1.8 ± 0.5 1.3 ± 0.1 1.6 ± 0.2*
  1. Values are presented as means ± standard deviations (n = 4-5). Significance levels are given for Cy/+ versus +/+ animals and Cy/+ plus lovastatin versus Cy/+ animals: *p < 0.05, **p < 0.01; as determined by ANOVA (with post-hoc pairwise multiple comparison Tukey-test). Abbreviations: DAG: diacylglycerol, GPC: glycerophosphocholine, PUFA: polyunsaturated fatty acids, TAG: triacylglycerol.