Table 1 Concentration of water-soluble and lipid metabolites as calculated from rat kidney tissue samples using 1 H-NMR
Metabolite | +/+ | Cy/+ | Cy/+ plus lovastatin |
|---|---|---|---|
Acetate [nmol/g] | 553.6 ± 288.8 | 229.7 ± 139.3* | 272.2 ± 70.5 |
Alanine [nmol/g] | 1309.8 ± 300.6 | 1117.2 ± 412.1 | 938.3 ± 324.4 |
Allantoin [nmol/g] | 623.2 ± 237.7 | 1572.1 ± 257.1** | 1150.1 ± 227.4* |
Aspartate [nmol/g] | 584.0 ± 98.2 | 381.1 ± 30.5* | 572.7 ± 75.9** |
Citrate [nmol/g] | 1366.9 ± 296.8 | 919.3 ± 150.7* | 1419.2 ± 92.2** |
Glucose [nmol/g] | 1145.5 ± 237.9 | 806.5 ± 113.2* | 674.1 ± 104.6* |
Glutamate [nmol/g] | 4615.0 ± 461.6 | 3669.4 ± 806.1* | 3690.8 ± 933.9 |
Glutamine [nmol/g] | 1437.1 ± 724.0 | 1385.9 ± 303.4 | 1087.4 ± 425.7 |
Glycine [nmol/g] | 4763.2 ± 2284.7 | 3173.1 ± 391.1 | 4999.2 ± 2408.0 |
GPC [nmol/g] | 696.9.3 ± 48.2 | 541.8 ± 122.2* | 631.3 ± 222.5 |
3-Hydroxybutyrate [nmol/g] | 442.7 ± 118.8 | 301.2 ± 43.8* | 335.4 ± 97.6 |
Lactate [nmol/g] | 4480.7 ± 1303.0 | 4729.8 ± 696.7 | 5876.9 ± 393.5* |
Myo-inositol [nmol/g] | 8170.4 ± 1606.9 | 8789.3 ± 2184.8 | 9258.2 ± 2478.2 |
Succinate [nmol/g] | 3353.4 ± 278.2 | 2219.6 ± 557.0** | 2160.9 ± 420.3 |
Taurine [μmol/g] | 12.0 ± 3.7 | 11.5 ± 1.6 | 11.7 ± 2.4 |
TAG/DAG [μmol/g] | 8.5 ± 2.2 | 5.1 ± 0.8* | 5.9 ± 2.2 |
Δ-2 PUFA [μmol/g] | 12.1 ± 2.2 | 8.0 ± 0.7* | 10.0 ± 2.4 |
Cholines [μmol/g] | 1.8 ± 0.5 | 1.3 ± 0.1 | 1.6 ± 0.2* |