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Table 2 Markers of oxidative stress

From: Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease

 

CAD

No CAD

P-value

n = 100

n = 93

CAD vs no CAD

 

eGFR ≥60 mL/min

eGFR <60 mL/min

P-value

eGFR ≥60 mL/min

 
 

n = 67

n = 33

   

GSH (μmol/L)

992 [227]

894 [399]

0.067

1067 [270]

0.001

GSSG (μmol/L)

29.0 [63.5]

25.6 [71.1]

0.904

1.94 [24.5]

<0.001

GSH/GSSG ratio

32.9 [569]

32.6 [513]

0.636

177 [709]

0.001

OxLDL (AU)

59.5 [35.6]

50.2 [33.6]

0.111

54.8 [24.5]

0.847

OxLDL/LDL ratio (AU/mmol/L)

28.5 [16.9]

28.4 [10.9]

0.612

17.6 [5.7]

<0.001

Whole blood superoxide release (nmol/min/106 celles)

1.6 [2.2]

1.3 [1.0]

0.143

1.2 [0.6]

0.012

Basal mononuclear cell superoxide release (nmol/min/106 cells)

2.5 [2.0]

2.2 [1.8]

0.504

1.8 [1.0]

0.005

Maximum (PMA) mononuclear cell superoxide release (nmol/min/106 cells)

28.1 [21.2]

30.5 [23.4]

1.000

14.7 [9.7]

<0.001

Fold change in mononuclear cell superoxide release

12.9 [7.1]

15.4 [9.2]

0.391

8.5 [5.4]

<0.001

  1. CAD coronary artery disease, GSH reduced glutathione, GSSG oxidised glutathione, OxLDL oxidised low density lipoprotein cholesterol, PMA phorbol-12-myristate-13-acetate. Data are given as median [interquartile range]. P-values are derive from Mann–Whitney U-tests.
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BMC Nephrology

ISSN: 1471-2369

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