Table 3 Circulating biomarkers

From: Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease

	CAD			No CAD
	n = 109			n = 86
	eGFR ≥60 mL/min	eGFR <60 mL/min	P-value	eGFR ≥60 mL/min	eGFR <60 mL/min	P-value
	n = 71	n = 38		n = 40	n = 46
E-selectin (ng/mL)	10.5 [10.4]	17.6 [12.6]	<0.001	10.8 [6.6]	19.2 [14.2]	<0.001
P-selectin (ng/mL)	90.4 [39.0]	106.1 [57.9]	0.015	85.6 [45.9]	113.0 [45.9]	0.001
ICAM-1 (ng/mL)	27.6 [11.4]	34.5 [21.9]	0.002	23.0 [12.6]	33.1 [15.6]	<0.001
VCAM-1 (μg/mL)	1.37 [1.26]	2.03 [1.36]	0.006	0.96 [0.75]	1.42 [0.95]	0.008
sRAGE (ng/mL)	3.8 [2.5]	4.8 [4.7]	0.110	3.8 [3.0]	6.7 [5.9]	<0.001
ENRAGE (ng/mL)	73.2 [81.0]	65.3 [149.9]	0.794	53.9 [56.9]	38.3 [32.2]	0.059
IL-8 (pg/mL)	4.0 [3.7]	3.8 [4.1]	0.218	3.2 [3.0]	5.1 [4.4]	0.005
MCP-1 (pg/mL)	44.6 [31.8]	50.8 [48.1]	0.488	54.9 [40.2]	70.3 [53.7]	0.009
MIP-1β (pg/mL)	66.2 [50.4]	73.5 [56.5]	0.258	66.4 [48.2]	95.0 [91.1]	0.029
CRP (mg/L)	2.0 [2.2]	2.4 [2.9]	0.138	1.3 [1.9]	2.9 [4.8]	<0.001
TNF-α (pg/mL)	0.73 [1.14]	0.96 [1.63]	0.182	0.65 [0.62]	1.73 [1.29]	<0.001
PAI-1(ng/mL)	219.0 [198.6]	152.5 [265.8]	0.329	175.8 [221.0]	153.8 [101.8]	0.044
Adiponectin (μg/mL)	4.1 [3.9]	5.6 [6.9]	0.020	3.5 [4.6]	5.9 [9.3]	0.047
Osteopontin(ng/mL)	0.5 [1.0]	1.8 [4.0]	<0.001	0.0 [0.9]	9.4 [17.9]	<0.001
Leptin (ng/mL)	9.1 [8.0]	15.0 [27.3]	0.011	6.4 [9.0]	16.3 [28.8]	<0.001

CAD coronary artery disease, eGFR estimated glomerular filtration rate, ICAM-1 intercellular adhesion molecule-1, VCAM-1 vascular cell adhesion molecule-1, sRAGE soluble receptor of advanced glycation end-products, ENRAGE extracellular newly identified receptor for advanced glycation end-products binding protein, MCP-1 monocyte chemoattractant protein 1, MIP-1β macrophage inflammatory protein-1 beta, CRP C-reactive protein, TNF-α, tumour necrosis factor alpha, PAI-1 plasminogen activator inhibitor-1. Data are given as median [interquartile range]. P-values refer to comparisons between the eGFR ≥60 mL/min and eGFR <60 mL/min groups.

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