Estimation of glomerular filtration rate by a radial basis function neural network in patients with type-2 diabetes mellitus

Table 2 Glomerular filtration rates (sGFR, eGFR ₄ , eGFR ₆ , and eGFR _RBF ) of patients with different stages of CKD

Measurement method (mL/min/1.73 m²)	Total¹(n = 207)	Stage I/II¹(n = 64)	Stage III¹(n = 81)	Stage IV/V¹(n = 62)	P-value
sGFR	43.45 (25.35 , 64.36)	78.39 (66.86 , 87.89)	43.42 (35.81 , 54.82)^a	19.70 (14.58 , 23.19)^ab	<0.001^*
eGFR₄	42.43 (15.68 , 75.46)	89.12 (67.73 , 124.20)^†	42.43 (26.50 , 59.31)^a	9.60 (6.71 , 17.11)^ab†	<0.001^*
eGFR₆	39.98 (15.28 , 72.28)^‡	90.88 (64.52 , 116.84)^‡	40.21 (24.72 , 60.54)^a‡	9.92 (6.54 , 17.02)^ab†	<0.001^*
eGFR_RBF	52.25 (34.21 , 81.64)^†‡§	94.23 (70.34 , 115.27)^†	50.42 (39.61 , 70.57)^a†‡§	24.01 (18.70 , 37.28)^ab†‡§	<0.001^*

Abbreviations here and in Tables 3: sGFR standard GFR, eGFR ₄ GFR estimated by re-expressed MDRD-4, eGFR ₆ GFR estimated by re-expressed MDRD-6, eGFR _RBF GFR estimated by RBF network.
¹ Data are given as medians and IQRs for continuous variables because of non-normal distributions; differences among CKD stages were compared using the Kruskall Wallis test with a post hoc method, or the Mann–Whitney U test for pair-wise comparisons; within-group comparisons of the four measurements were performed using Wilcoxon Signed Ranks Test for a given CKD stage.
*p < 0.05, indicates significant difference among CKD stages.
^a,b p < 0.0167 (0.05/3), indicates significant difference in a comparison of CKD stage I/II and III, respectively.
^†,‡,§, p < 0.01 (0.05/4), indicates significant difference in a comparison with sGFR, eGFR₄, and eGFR₆, respectively.

ISSN: 1471-2369