Variables | Control | Stage 3 | Stage 4 | Stage 5 | P |
---|---|---|---|---|---|
(CG = 9) | (G3 = 10) | (G$ = 10) | (G5 = 9) | ||
Age (years) | 51.5 ± 7.5 | 56.8 ± 5.8 | 52.3 ± 8.5 | 56.3 ± 9.0 | 0.351 |
Sex (F/M) | 4/5 | 5/5 | 6/4 | 5/4 | 0.914 |
BMI (kg/m2) | 27.2 ±4.6 | 29.5 ± 5.7 | 26.3 ± 6.5 | 27.9 ± 5.6 | 0.655 |
CKD Etiology: | |||||
Hypertensive Nx | - | 5 | 3 | 2 | <0.001* |
Diabetic Nx | - | 1 | 2 | 2 | |
CGN | - | 1 | 2 | 3 | |
Others | - | 3 | 3 | 2 | |
Comorbidities: | |||||
H | - | 10 | 9 | 9 | <0.001* |
DM | - | 2 | 4 | 2 | <0.001* |
Dyslipidemia | - | 6 | 6 | 8 | <0.001* |
eGFR (mL/min/1.73m2) | 77.6 ± 9.8b,c,d | 43.8 ± 8.7a,c,d | 21.3 ± 4.2a,b,d | 12.7 ± 3.7a,b,c | <0.001* |
Creatinine (mg/dL) | 0.9 ± 0.1b,c,d | 1.5 ± 0.2a,c,d | 2.7 ± 0.6a,b,d | 4.4 ± 1.3a,b,c | <0.001* |
Potassium (meq/L) | 4.6 ± 0.4d | 4.4 ± 0.5d | 4.7 ± 0.9 | 5.4 ± 0.9 | 0.049 |
Calcium (mg/dL) | 10.0 ± 0.6 | 9.9 ± 1.0 | 9.9 ± 0.7 | 10.2 ± 0.6 | 0.852 |
Phosphorus (mg/dL) | 4.8 ± 2.2 | 3.6 ± 0.6 | 4.1 ± 0.8 | 4.9 ± 0.6 | 0.081 |
Alkaline phosphatase (U/L) | 155.2 ± 41.1d | 193.8 ± 38.3d | 220.1 ± 51.1d | 305.5 ± 144.7 | 0.014 |
PTHi (pg/mL) | 71.2 ± 29.8d | 77.0 ± 24.9d | 114.2 ± 52.2d | 337.2 ± 283.0 | 0.004 |
Hemoglobin (g/dL) | 15.0 ± 1.8c,d | 13.7 ± 1.4c | 12.3 ± 1.3 | 12.3 ± 1.6 | 0.003 |
Albumin (g/dL) | 3.9 ± 0.1 | 4.2 ± 0.3 | 3.6 ± 0.5 | 4.2 ± 0.5 | 0.102 |
Total cholesterol (mg/dL) | 201.6 ± 41.5 | 207.8 ± 43.5 | 190.6 ± 40.7 | 215.4 ± 59.3 | 0.698 |
Triglycerides (mg/dL) | 106.5 ± 45.9 | 147.6 ± 81.8 | 179.1 ± 120.0 | 252.1 ± 221.3 | 0.163 |
HCO3 (mmol/L) | 28.0 ± 0.8c,d | 27.3 ± 2.5c,d | 23.7 ± 3.8 | 22.0 ± 4.5 | 0.003 |