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Table 3 Pooled hazard ratio for cardiovascular mortality in patients receiving vitamin D or no treatment

From: Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studies

Patient groups # patients Hazard ratio # studies I2, %
Crude cardiovascular mortality using baseline Cox model     
 Alfacalcitol vs no treatment 432 0.37 (0.25–0.55) 2 0
 Calcitrol vs no treatment 1889 0.57 (0.46–0.71) 1 NA
 Paricalcitol vs no treatment 1230 0.31 (0.22–0.44) 1 NA
 Overall 3551 0.41 (0.28–0.59) 4 69.9
Adjusted cardiovascular mortality using baseline Cox model     
 Any vitamin D vs no treatment 466 0.59 (0.19–1.82) 2 68.6
 Alfacalcitol vs no treatment 665 0.45 (0.14–1.47) 1 NA
 Calcitrol vs no treatment 1889 0.63 (0.50–0.79) 1 NA
 Paricalcitol vs no treatment 1230 0.43 (0.29–0.63) 1 NA
 Overall 4250 0.59 (0.41–0.86) 5 83.6