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Table 4 Hazard ratios for all-cause mortality by ESA and Hb category

From: Erythropoiesis-stimulating agent resistance and mortality in hemodialysis and peritoneal dialysis patients

     All-cause mortality  
ESA (units/week) Hb (g/dL) Patients (n) Unadjusted HR   Adjusted HR1   Adjusted HR2
HD patients      
  ≤8,000 ≥11 380 1   1   1
  ≤8,000 <11 264 1.29 (1.01-1.65)   1.33 (1.04-1.70)   1.18 (0.91-1.52)
  >8,000 ≥11 158 1.35 (1.01-1.80)   1.52 (1.13-2.04)   1.28 (0.94-1.73)
  >8,000 <11 211 1.72 (1.34-2.20)   1.91 (1.48-2.47)   1.37 (1.04-1.80)
PD patients      
  ≤4,000 ≥11 204 1   1   1
  ≤4,000 <11 91 1.59 (0.96-2.63)   1.94 (1.15-3.27)   1.56 (0.91-2.68)
  >4,000 ≥11 113 2.55 (1.66-3.92)   1.89 (1.20-2.97)   1.56 (0.96-2.51)
  >4,000 <11 53 2.34 (1.34-4.10)   3.18 (1.74-5.79)   2.41 (1.27-4.57)
  1. Values are shown as hazard ratios (95% CI).
  2. Categories are defined by a combination of ESA dose (below or from median) and Hb level (≥11 and <11 g/dL). The category with the high ESA dose and Hb <11 corresponds to ESA resistant patients and the category with the low ESA dose and Hb ≥11 corresponds to good ESA responders.
  3. 1 Adjusted for age, sex, weight, primary kidney disease, diabetes mellitus, malignancy, cardiovascular disease.
  4. 2 Additional adjusted for weekly Kt/V urea, rGFR, nutritional status, albumin, ferritin, PTH and CRP.