Effects of isotonic 0.9% saline (■), hypertonic 3% saline (♦) and isotonic glucose (●) on plasma renin (A), plasma angiontensin II (B) and plasma aldosterone (C) concentrations. Values are expressed as mean ± SEM. General linear model (GLM) with repeated measures within subjects was significant for all three variables. Paired t-test was used for comparison within treatment groups at postinfusion 240 min vs. basal. * p < 0.0001.