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Table 5 Pre-dialysis mean serum level of bicarbonate, phosphate, potassium and corrected calcium for different combinations of phosphate binders

From: Differential effects of phosphate binders on pre-dialysis serum bicarbonate in end-stage kidney disease patients on maintenance haemodialysis

 

June 2009

December 2009

June 2010

 

Mean (SD)#

Mean difference (95% CI)*

P

Mean (SD)#

Mean difference (95% CI)*

P

Mean (SD)#

Mean difference (95% CI)*

P

 

Bicarbonate

       

Group A (Ca & Al)

22.94 (2.83)

ref

 

22.89 (2.76)

ref

 

22.98 (2.77)

ref

 

Group B (SH)

21.26 (2.72)

-1.56 (-2.09 to -1.02)

<0.001

21.25 (2.83)

-1.18 (-1.59 to -0.78)

<0.001

21.58 (2.82)

-0.95 (-1.29 to -0.60)

<0.001

Group C (LC)

22.83 (1.17)

-0.01 (-2.76 to 2.74)

0.98

23.76 (2.57)

0.74 (0.05 to 1.43)

0.04

23.29 (2.80)

0.58 (0.10 to 1.05)

0.02

Group D (SH & Ca/Al)

21.17 (3.00)

-1.30 (-1.83 to -0.77)

<0.001

21.31 (3.00)

-0.69 (-1.10 to -0.29)

<0.001

21.56 (3.00)

-0.64 (-1.00 to -0.28)

<0.001

Group E (LC & Ca/Al)

19.50 (4.45)

-1.40 (-2.79 to 0.00)

0.05

20.59 (3.59)

-0.44 (-1.09 to 0.22)

0.19

21.29 (3.62)

-0.03 (-0.54 to 0.49)

0.92

 

Phosphate ^

       

Group A (Ca & Al)

1.53 (0.51)

ref

 

1.52 (0.50)

ref

 

1.50 (0.49)

ref

 

Group B (SH)

1.48 (0.41)

-0.01 (-0.10 to 0.08)

0.83

1.52 (0.44)

0.03 (-0.04 to 0.10)

0.35

1.52 (0.45)

-0.01 (-0.07 to 0.05)

0.70

Group C (LC)

1.73 (0.63)

0.32 (-0.12 to 0.77)

0.16

1.67 (0.54)

0.08 (-0.04 to 0.19)

0.18

1.67 (0.53)

0.04 (-0.03 to 0.12)

0.27

Group D (SH & Ca/Al)

1.73 (0.57)

0.08 (-0.02 to 0.17)

0.11

1.70 (0.54)

0.02 (-0.05 to 0.09)

0.65

1.68 (0.55)

0.00 (-0.06 to 0.06)

0.97

Group E (LC & Ca/Al)

2.12 (0.58)

0.29 (0.05 to 0.52)

0.02

2.09 (0.74)

0.16 (0.06 to 0.27)

0.003

2.01 (0.77)

0.06 (-0.02 to 0.15)

0.14

 

Potassium

       

Group A (Ca & Al)

4.84 (0.70)

ref

 

4.82 (0.69)

ref

 

4.83 (0.70)

ref

 

Group B (SH)

5.04 (0.71)

0.14 (0.01 to 0.27)

0.04

5.03 (0.72)

0.17 (0.07 to 0.27)

<0.001

5.05 (0.70)

0.16 (0.08 to 0.24)

<0.001

Group C (LC)

4.87 (0.36)

0.21 (-0.45 to 0.87)

0.54

4.76 (0.74)

-0.02 (-0.18 to 0.14)

0.84

4.84 (0.81)

0.05 (-0.06 to 0.16)

0.38

Group D (SH & Ca/Al)

5.18 (0.72)

0.20 (0.06 to 0.33)

<0.001

5.13 (0.69)

0.14 (0.04 to 0.23)

0.01

5.12 (0.68)

0.15 (0.06 to 0.23)

<0.001

Group E (LC & Ca/Al)

5.09 (0.62)

0.18 (-0.16 to 0.51)

0.30

5.01 (0.79)

-0.04 (-0.19 to 0.12)

0.63

5.08 (0.77)

0.03 (-0.10 to 0.15)

0.68

 

Corrected Calcium ^

       

Group A (Ca & Al)

2.35 (0.19)

ref

 

2.35 (0.18)

ref

 

2.37 (0.18)

ref

 

Group B (SH)

2.33 (0.19)

-0.03 (-0.06 to 0.01)

0.14

2.33 (0.19)

-0.03 (-0.06 to -0.01)

0.01

2.34 (0.19)

-0.04 (-0.06 to -0.02)

<0.001

Group C (LC)

2.18 (0.15)

-0.12 (-0.30 to 0.05)

1.17

2.36 (0.18)

-0.01 (-0.05 to 0.03)

0.73

2.39 (0.18)

0.01 (-0.02 to 0.04)

0.60

Group D (SH & Ca/Al)

2.30 (0.20)

-0.05 (-0.09 to -0.02)

0.004

2.31 (0.19)

-0.04 (-0.06 to -0.01)

0.003

2.32 (0.19)

-0.04 (-0.06 to -0.02)

<0.001

Group E (LC & Ca/Al)

2.30 (0.23)

-0.03 (-0.12 to 0.06)

0.56

2.28 (0.22)

-0.01 (-0.05 to 0.03)

0.50

2.30 (0.21)

-0.02 (-0.05 to 0.01)

0.29

  1. Group A (Calcium and/or Aluminium binders).
  2. Group B (Sevelamer hydrochloride alone).
  3. Group C (Lanthanum carbonate alone).
  4. Group D (Sevelamer hydrochloride and Calcium and/or Aluminium binders).
  5. Group E (Lanthanum carbonate and Calcium and/or Aluminium binders).
  6. #Observed mean level in mmol/L (standard deviation).
  7. *Estimated mean difference in mmol/L (95% confidence interval) after adjusted for sex, age and diabetes.
  8. ^for those patients who had no parathyroidectomy.