Figure 2

Decrease of mitochondrial proteins and DNA in the rat kidneys after PNx surgery. Representative Western blots (A) and densitometry analysis (B) shows down regulation of MCAD (n = 6), COXIV (n = 6) and GRP-75 (n = 11) in PNx rats when compared to the sham operated controls. *p < 0.05, **p < 0.01. C - Sham operated control cortex contains approx. 450 copies of mitochondrial genes COX II and Cytochrom B per nuclear actin gene. Renal mass ablation PNx results in a decrease of mitochondrial DNA below 300 copies per actin. n ≥ 15, *p < 0.05, **p < 0.01.