Skip to main content

Table 2 Medians and 25th-75th percentiles (P25-P75) of log10 mRNA of podocyte-associated proteins in urine by stage of diabetic nephropathy, in subjects with prediabetes and in controls

From: Messenger RNA levels of podocyte-associated proteins in subjects with different degrees of glucose tolerance with or without nephropathy

 

Diabetes

 

Log 10 mRNA Urinary

Controls (n = 15)

Prediabetes (n = 19)

Normoalbuminuria (n = 34)

Microalbuminuria (n = 14)

Macroalbuminuria (n = 19)

p-value

Nephrin

2.03(1.49-2.67)

2.03(1.20-2.93)

2.85(2.14-3.63)

3.35(2.14-5.48)

4.21(3.16-4.95)

<0.001

Podocin

1.57(1.32-2.33)

2.22(1.83-3.25)

2.67(2.12-4.00)

2.54(1.72-3.99)

2.33(1.64-3.62)

0.150

Podocalyxin

1.68(1.18-2.53)

2.10(1.41-2.83)

3.04(2.35-3.76)

3.51(2.79-5.13)

2.89(2.69-3.42)

<0.001

Synaptopodin

1.72(1.30-2.60)

1.86(1.22-2.29)

2.93(1.88-3.12)

2.61(1.13-3.33)

1.62(1.02-4.30)

0.112

TRPC6

1.97(1.21-2.83)

1.69(0.97-2.53)

3.06(1.96-3.83)

2.40(1.89-4.17)

3.06(2.25-4.29)

0.001

Alpha actinin-4

1.94(1.24-3.11)

2.44(1.74-2.67)

3.26(2.48-4.23)

3.54(2.45-4.75)

2.70(2.38-4.08)

<0.001

TGFβ1

2.21(0.78-2.96)

2.59(1.98-3.30)

2.75(2.25-3.86)

2.31(1.40-4.18)

3.02(1.97-4.15)

0.241

  1. Controls: C; Prediabetes: PD; Diabetes with normoalbuminuria: NO; Diabetes with microalbuminuria: MI; Diabetes with macroalbuminuria: MA.
  2. Nephrin: MA vs. C and PD (P<0.001); MI vs. PD and MA vs. NO (P<0.05); MI vs. C, NO vs. C and PD (P<0.05).
  3. Podocalyxin: MI vs. C (P<0.001); MA vs. C, NO vs. C, and MI vs. PD (P<0.05); NO vs. PD (P=0.035).
  4. TRPC6: MA vs. PD and NO vs. PD (P<0.05); MA vs. C (P=0.049).
  5. Alpha actinin-4: NO vs. PD and C (P<0.05); MI vs. PD (P=0.032).